Profiles of parabens, benzophenone-type ultraviolet filters, triclosan, and triclocarban in paired urine and indoor dust samples from Chinese university students: Implications for human exposure
Profiles of parabens, benzophenone-type ultraviolet filters, triclosan, and triclocarban in paired urine and indoor dust samples from Chinese university students: Implications for human exposure
复制标题
中国大学生配对尿液和室内灰尘样本中对羟基苯甲酸酯、二苯甲酮型紫外线过滤剂、三氯生和三氯卡班的含量分析：对人体暴露的影响
DOI：
10.1016/j.scitotenv.2021.149275
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发表时间：
2021
影响因子：
9.8
通讯作者：
Gao Yunfei
中科院分区：
文献类型：
--
作者：
Zhang Hua;Li Jingxia;Chen Yanfang;Wang Desheng;Xu Weiguo;Gao Yunfei
对羟基苯甲酸酯、二苯甲酮（BP）型紫外线过滤剂、三氯生（TCS）和三氯卡班（TCC）通常用于个人护理产品。由于这些化合物对健康的不利影响，人类接触这些化合物已受到越来越多的关注。然而，这些化学物质在成对的尿液和室内样本中的水平从未被同时测量过。在这项工作中，八个对羟基苯甲酸酯，八个BP型紫外线过滤器，TCS和TCC的配对尿液和室内灰尘样品收集在中国南方的大学生和他们的宿舍。目标分析物通常在尿液（71%-100%）和室内灰尘（30%-98%）中检测到，尿液中的中位浓度范围为0.16 ng/mL至19.3 ng/mL，室内灰尘样品中的中位浓度范围为<0.01 ng/g至3700 ng/g。女性中大多数目标化合物的水平较高，大多数目标分析物的水平存在性别相关差异。尿液和室内灰尘样品中尼泊金甲酯、尼泊金乙酯、二苯甲酮-3和TCS的水平呈正相关。这一发现表明，室内灰尘是人类接触这些化合物的重要来源。还评价了配对样本中这些分析物的估计每日摄入量（EDI）。目标分析物的中位尿EDI值在4.02- 59，280 ng/kg bw/天范围内变化。女性的大多数目标分析物的中位EDI-尿液评价值高于男性。女生宿舍灰尘中大多数目标物的EDI-室内灰尘值中位数均高于男生宿舍灰尘。室内灰尘摄入对总暴露量的贡献很小（<0.5%）。据作者所知，这项研究是第一个同时分析对羟基苯甲酸酯，BP型紫外线过滤剂，TCS和TCC的浓度在配对的尿液和室内样本，从华南地区的大学生。
Parabens, benzophenone (BP)-type UV filters, triclosan (TCS), and triclocarban (TCC) are commonly used in personal care products. Human exposure to these compounds has received increasing concern because of their adverse health effects. However, the levels of these chemicals in paired urine and indoor samples have never been simultaneously measured. In this work, eight parabens, eight BP-type UV filters, TCS, and TCC were measured in paired urine and indoor dust samples collected from university students and their dormitories in South China. The target analytes were commonly measured in urine (71%–100%) and indoor dust (30%–98%), with median concentrations ranging from 0.16 ng/mL to 19.3 ng/mL in urine and from <0.01 ng/g to 3700 ng/g in indoor dust samples. Females had high levels of most of these target compounds, and gender-related differences were found in the levels of most target analytes. Positive correlations were found in the levels of methylparaben, ethyl paraben, benzophenone-3, and TCS between urine and indoor dust samples. This finding suggested that indoor dust is an important source for human exposure to these compounds. The estimated daily intake (EDI) of these analytes in paired samples was also evaluated. The median EDI-urinevalues of target analytes varied in the range of 4.02–59,280 ng/kg bw/day. Females had higher median EDI-urinevalues for most of target analytes than males. In addition, the median EDI-indoor dustvalues of most target analytes in dust from female dormitories were higher than those in dust from male dormitories. Indoor dust ingestion only had minor contribution (<0.5%) to the total exposure. To the best of the authors' knowledge, this study is the first to simultaneously analyze the concentrations of parabens, BP-type UV filters, TCS, and TCC in the paired urine and indoor samples from university students in South China.