Iminosugars-From Synthesis to Therapeutic Applications
Iminosugars-From Synthesis to Therapeutic Applications
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DOI：
10.1097/mjt.0b013e318172886d
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发表时间：
2009-03
影响因子：
4.2
通讯作者：
V. Ranade
中科院分区：
文献类型：
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作者：
V. Ranade
说明：亚胺糖无疑是迄今为止报道的最有吸引力的碳水化合物模拟物。在这些结构中，糖的内环氧被碱性氮原子取代，导致了显著的生物学性质，并在有机合成中提出了许多挑战。自从1970年S发现其作为糖苷酶抑制剂的生物活性以来，这些多价分子逐渐从实验室进入临床。过去十年来该领域令人印象深刻的一系列发现清楚地表明，这是亚胺糖化学和生物学的繁荣时期。它们作为抑制剂的范围已经扩展到一些酶，如磷酸酶、糖基转移酶或金属蛋白酶，亚氨糖现在是开发新的治疗药物的先导化合物，包括糖尿病、病毒感染、溶酶体储存障碍和肿瘤转移。这本书介绍了从亚胺糖的合成到它们在临床研究中的使用的最新进展，其中包含了这个迅速扩大的领域中超过15位主要化学家、生物化学家和药物开发商的贡献。书中还包括一张广泛的表格，将600多种具有治疗意义的亚氨糖的结构与其生物活性联系起来，应该被证明对帮助设计和发现新的生物活性物质特别有用。亚胺糖：从合成到治疗应用为在生物和/或治疗领域从事亚胺糖和糖仿制的学术和工业研究人员提供了独特的资源：有机化学家、药物化学家、碳水化合物化学家和医学科学家。
Description: Iminosugars form undoubtedly the most attractive class of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970 s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is a boom time for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.