Sodium nuclear magnetic resonance imaging of neuroblastoma in the nude mouse.
Sodium nuclear magnetic resonance imaging of neuroblastoma in the nude mouse.
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DOI：
10.1097/00004424-199103000-00007
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发表时间：
1991-03
影响因子：
6.7
通讯作者：
R. Summers;P. Joseph;H. Kundel
中科院分区：
文献类型：
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作者：
R. Summers;P. Joseph;H. Kundel
已知的是，相对于正常组织，一些肿瘤中的平均钠浓度升高，而坏死被怀疑是可能的原因。我们在1.9特斯拉的小口径动物成像系统上对裸鼠体内的IMR-5神经母细胞瘤进行了体内-23钠磁共振成像(MRI)。我们将钠图像与组织学坏死分析、质子图像、水和血液含量的化学测量以及钠和钾浓度进行了比较。我们发现，核磁共振测定的钠浓度与肿瘤组织坏死的比例成正比。相关系数从0.65到0.78不等，这取决于数据的选择方式。通过进一步的改进，MRI无创性测定的钠浓度测量有可能应用于软组织肿瘤的临床诊断和分期。
The average concentration of sodium is known to be elevated in some tumors relative to normal tissues, and necrosis is suspected of being a possible cause. We have performed in vivo sodium-23 magnetic resonance imaging (MRI) of IMR-5 neuroblastoma in the athymic nude mouse on a 1.9-Tesla, small-bore animal imaging system. We compared the sodium images with histologic analysis for necrosis and with proton images, chemical measurements of water and blood content, and sodium and potassium concentrations. We found that the sodium concentrations determined by MRI were proportional to the fraction of the tumor tissue that was necrotic. Correlation coefficients varied from 0.65 to 0.78, depending upon how the data were selected. With further refinement it is possible that the sodium concentration measurements determined noninvasively by MRI may have applications as part of clinical diagnosis and staging of soft tissue tumors.