Biomaterials for hollow organ tissue engineering.
Biomaterials for hollow organ tissue engineering.
复制标题
DOI：
10.1186/s13069-016-0040-6
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Day RM
中科院分区：
文献类型：
--
作者：
Hendow EK;Guhmann P;Wright B;Sofokleous P;Parmar N;Day RM
组织工程是一个快速发展的领域，很可能在不久的将来改变医学的实践方式。对于诸如在心血管和呼吸系统或胃肠道中发现的中空器官，组织工程可以提供整个器官的替代或提供特定区域的功能恢复。较大的组织工程化构建物通常需要基于生物材料的支架结构来为新组织生长提供支撑和结构。必须考虑材料和制造工艺的选择，以确保新生组织与天然组织的机械和生理特性密切匹配。本文将讨论一些方法来制作中空器官支架和选择合适的生物材料。
Tissue engineering is a rapidly advancing field that is likely to transform how medicine is practised in the near future. For hollow organs such as those found in the cardiovascular and respiratory systems or gastrointestinal tract, tissue engineering can provide replacement of the entire organ or provide restoration of function to specific regions. Larger tissue-engineered constructs often require biomaterial-based scaffold structures to provide support and structure for new tissue growth. Consideration must be given to the choice of material and manufacturing process to ensure the de novo tissue closely matches the mechanical and physiological properties of the native tissue. This review will discuss some of the approaches taken to date for fabricating hollow organ scaffolds and the selection of appropriate biomaterials.