Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adults.
Metabolic predictors of inflammation, adhesion, and coagulability in healthy younger-aged adults.
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健康年轻人炎症、粘连和凝血能力的代谢预测因子。
DOI：
10.1038/oby.2008.420
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Rutledge,ThomasR
中科院分区：
文献类型：
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作者：
Mills,PaulJ;Shapiro,David;Goldstein,IrisB;Ottaviani,Cristina;Pung,MeredithA;Khandrika,Srikrishna;vonKanel,Roland;Rutledge,ThomasR
炎症生物标志物水平升高与心血管疾病的病理生理学相关，并且是心血管事件的预测因子。本研究的目的是确定代谢因素作为健康年轻成人炎症（C反应蛋白（CRP）和白细胞介素-6（IL-6））、粘附（可溶性细胞间粘附分子-1（sICAM-1））和凝血（D-二聚体）预测因子的独特贡献。参与者为83名女性和92名男性（平均年龄30.04岁，s.d.± 4.8，范围22-39）的正常体重至中度肥胖体重（平均BMI 24.4 kg/m2，s.d.± 3.35，范围17-32）。主要资料分析方法包括皮尔逊相关及多元线性回归。测定血浆中CRP、IL-6、sICAM-1和D-二聚体的循环水平。较高的CRP水平与较高的BMI、较大的腰臀比、女性和较高的甘油三酯独立相关（P< 0.001）。较高的IL-6水平与较大的腰臀比独立相关（P< 0.01）。较高水平的sICAM-1与较高的BMI、较高的甘油三酯和较低的胰岛素抵抗独立相关（P< 0.001）。较高的D-二聚体水平与较高的BMI和女性独立相关（P< 0.001）。在该健康年轻成人样本中，BMI较高与炎症、粘连和凝血生物标志物升高最相关，尽管女性性别、胰岛素抵抗和脂质水平也与生物标志物相关。这些发现为了解与年轻人体重升高相关的不良心血管风险提供了见解。
Elevated levels of inflammatory biomarkers are associated with the pathophysiology of cardiovascular diseases and are predictors of cardiovascular events. The objective of this study was to determine the unique contributions of metabolic factors as predictors of inflammation (C‐reactive protein (CRP) and interleukin‐6 (IL‐6)), adhesion (soluble intercellular adhesion molecule‐1 (sICAM‐1)), and coagulation (D‐dimer) in healthy younger‐aged adults. Participants were 83 women and 92 men (mean age 30.04 years, s.d. ± 4.8, range 22–39) of normal weight to moderate obese weight (mean BMI 24.4 kg/m2, s.d. ± 3.35, range 17–32). The primary data analytical approaches included Pearson correlation and multiple linear regression. Circulating levels of CRP, IL‐6, sICAM‐1, and D‐dimer were determined in plasma. Higher levels of CRP were independently associated with higher BMI, a greater waist‐to‐hip ratio, female gender, and higher triglycerides (P< 0.001). Higher IL‐6 levels were independently associated with a greater waist‐to‐hip ratio (P< 0.01). Higher levels of sICAM‐1 were independently associated with higher BMI, higher triglycerides, and lower insulin resistance (P< 0.001). Higher D‐dimer levels were independently associated with higher BMI and being female (P< 0.001). Having a higher BMI was most consistently associated with elevated biomarkers of inflammation, adhesion, and coagulation in this sample of healthy younger‐aged adults, although female gender, insulin resistance, and lipid levels were also related to the biomarkers. The findings provide insight into the adverse cardiovascular risk associated with elevated body weight in younger adults.