The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains
The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains
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DOI：
10.1016/s0920-9964(99)00037-7
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发表时间：
1999-11-09
影响因子：
4.5
通讯作者：
Blennow, K
中科院分区：
文献类型：
--
作者：
Davidsson, P;Gottfries, J;Blennow, K
在精神分裂症患者和健康对照组的死后脑组织中，研究了两种突触-囊泡蛋白--Rab3a和突触素。我们发现，与对照组相比，精神分裂症患者丘脑(p<；0.001)、扣带回和海马区两种蛋白的表达水平显著降低(p<；0.0001)；额叶和顶叶皮质(p<；0.0001)的表达水平显著降低(p<；0.05)；而在颞叶皮质或小脑中的表达水平没有显著差异。突触密度降低可能是精神分裂症分子神经病理的一个显著特征。(C)1999 Elsevier Science B.V.保留所有权利。
Two synaptic-vesicle proteins, rab3a and synaptophysin, have been studied on post-mortem brain tissues of schizophrenics and healthy controls. We found significantly reduced levels of rab3a in thalamus (p < 0.001); for both proteins in gyrus cinguli and hippocampus (p < 0.0001); for rab3a in frontal and parietal cortex (p < 0.05); and no differences in temporal cortex or cerebellum in schizophrenics compared with controls. Reduced synaptic density may be a prominent feature of the molecular neuropathology of schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.