Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5%
Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5%
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DOI：
10.1016/j.vetpar.2004.12.020
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发表时间：
2005-04-20
影响因子：
2.6
通讯作者：
Otranto, D
中科院分区：
文献类型：
--
作者：
Bianciardi, P;Otranto, D
由Thelazia callipaeda引起的犬吸吮线虫病感染狗、猫、狐狸、兔子和人类，导致结膜炎、疼痛和过度流泪。T. callipaeda生活在瞬膜下的眼睛中，雌性释放第一阶段的幼虫，这些幼虫被作为中间宿主的苍蝇摄取。目前控制犬绦虫病的方法是直接从患病犬的眼睛中清除线虫或局部滴注抗寄生虫药物。为评价其对T.通过皮肤施用10%吡虫啉和2.5%莫昔克丁的组合的组合的calipaeda，选择三组自然感染的动物：即A组（21只狗）接受单剂量的10%吡虫啉和2.5%莫昔克丁的点涂; B组（21只狗）通过点涂接受单剂量的10%吡虫啉，C组（20只狗）不接受处理。在动物处理后1、5和9天（A组和B组）和9天后仅在未处理动物（C组）中通过眼睛检查和寄生虫存活力和活力确定处理功效。在给药后5（90.47%）至9（95.23%）天内，10%吡虫啉和2.5%莫昔克丁滴剂制剂对犬绦虫病的控制有效。仅A组1只犬在给药后出现线虫。B组（10%吡虫啉）和C组犬眼中寄生虫的存在证实了对T. A组动物（10%吡虫啉和2.5%莫昔克丁）中的calipaeda最可能归因于2.5%莫昔克丁。含有10%吡虫啉和2.5%莫昔克丁的滴剂制剂非常易于涂抹，有助于克服与机械清除寄生虫或在眼睛局部滴注药物时限制动物相关的问题。(c)2005 Elsevier B. V.保留所有权利。
Canine thelaziosis caused by Thelazia callipaeda infects dogs, cats, foxes, rabbits, and humans resulting in conjunctivitis, pain and excessive lacrimation. T. callipaeda live in the eyes under the nictitating membrane and females release first stage larvae which are ingested by flies which act as intermediate hosts. Control of canine thelaziosis is currently based on the removal of nematodes directly from the eyes of affected dogs or on the local instillation of antiparasitic drugs. With the aim of evaluating the efficacy against T. callipaeda of an association of imidacloprid 10% and moxidectin 2.5% by spot-on formulation administered via dermal application, three groups of naturally infected animals were selected: i.e. group A (21 dogs) received a single dose of imidacloprid 10% and moxidectin 2.5% by spot-on; group B (21 dogs) received a single dose of imidacloprid 10% by spot-on and group C (20 dogs) were left untreated. The efficacy of treatments was established by eye inspection and parasite viability and vitality after 1, 5 and 9 days after animal treatments (groups A and B) and after 9 days only in untreated animals (group C). Imidacloprid 10% and moxidectin 2.5% in spot-on formulation showed to be effective with regards the control of dog thelaziosis within 5 (90.47%) to 9 (95.23%) days after treatment. Only one dog from group A presented nematodes after treatment. The presence of parasites in the eyes of dogs from groups B (imidacloprid 10%) and C confirm that the anthelmintic efficacy against T. callipaeda in animal from group A (imidacloprid 10% and moxidectin 2.5%) was most likely attributable to moxidectin 2.5%. The spot-on formulation containing imidacloprid 10% and moxidectin 2.5% is very easy to apply and helps overcome problems linked to the mechanical removal of parasites or to the restraining of the animals for the local instillation of drugs in the eyes. (c) 2005 Elsevier B.V. All rights reserved.