Successful treatment of epilepsy with serotonin reuptake inhibitors: Proposed mechanism
Successful treatment of epilepsy with serotonin reuptake inhibitors: Proposed mechanism
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DOI：
10.1007/s11064-006-9045-7
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发表时间：
2006-04-01
影响因子：
4.4
通讯作者：
Favale, E.
中科院分区：
文献类型：
--
作者：
Albano, C.;Cupello, A.;Favale, E.
广泛使用的抗抑郁药特异性5-羟色胺再摄取抑制剂(SSRI)已被成功地作为抗癫痫药在无症状癫痫病例中试验。这一尝试是在实验数据的基础上进行的，这些数据表明5-羟色胺系统的损伤参与了癫痫的发生。本文综述了SSRI治疗无症状性癫痫的临床资料，并提供了生化和神经化学证据，提示SSRI治疗无症状癫痫的机制。特别是，对癫痫患者血液中中性氨基酸和血小板5-羟色胺转运体(SERT)的研究表明：(A)大脑色氨酸可获得性降低可能与某些类型的癫痫有关。(B)SERT密度降低可能是癫痫发作后大脑内的一种稳态反应。
The widely used antidepressants Specific Serotonin Reuptake Inhibitors (SSRI) have been tried with success as anticonvulsants in cases of nonsymptomatic epilepsy. This attempt was performed on the basis of experimental data suggesting the involvement of impairments of the serotonin system in the genesis of epilepsy. This overview summarizes the clinical data and presents biochemical and neurochemical evidences suggesting the mechanism of the therapeutic effects of SSRI in nonsymptomatic epilepsy. In particular, studies on blood-borne neutral amino acids and platelet serotonin transporter (SERT) in epileptics suggest: (a) That a decreased brain availability of tryptophan may be related to some types of epilepsy. (b) That reduction of the density of SERT may be a homeostatic reaction in the brain following epileptic seizures.