1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water
1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water
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1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
DOI：
10.1039/c7ob02329d
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发表时间：
2017
影响因子：
3.2
通讯作者：
Zhang Wei
中科院分区：
文献类型：
--
作者：
Ma Chunhua;Fan Guojie;Wu Ping;Li Zhi;Zhou Yang;Ding Qingjie;Zhang Wei
在水中，经1，3-二溴-5，5-二甲基海因处理，再与分子碘和AQ反应，可将多种端烯转化为相应的酰胺，产率为25%~86%。将NH3(或胺)放入一个锅中。这种无金属和有机溶剂的协议不仅适用于苯乙烯衍生物，而且首次对末端脂肪族烯烃起到了良好的作用。
A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot. This metal- and organic solvent-free protocol is not only suitable for styrene derivatives, but also, for the first time, works well on terminal aliphatic alkenes.