Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys.
Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys.
复制标题
通过对恒河猴的呼吸影响来测量对海洛因和吗啡的急性依赖，但不耐受。
DOI：
10.1016/s0014-2999(00)00279-x
复制
发表时间：
2000
影响因子：
5
通讯作者：
Woods,JH
中科院分区：
文献类型：
--
作者：
Kishioka,S;Paronis,CA;Woods,JH
Acute dependence on and tolerance to heroin and morphine were assessed in rhesus monkeys using measures of respiration. Respiratory frequency (f) and minute volume (Ve) were measured in monkeys breathing air or 5% CO2in air using a pressure-displacement plethysmograph. Cumulative doses of naltrexone (0.0001–1.0 mg/kg, i.m) did not alter these parameters in untreated monkeys. Twenty-four hours after a cumulative dose of heroin (1 mg/kg, i.m.), naltrexone produced an increase in both f and Vewhen monkeys were breathing air or 5% CO2. Following 1 to 3 days of treatment with heroin (0.5 mg/kg/day, i.m.) or morphine (16 mg/kg/day, i.m.), naltrexone produced an increase in f and Vethat was related to the dose of naltrexone and the number of days of agonist administration. Two days following termination of heroin administration, naltrexone-induced respiratory stimulation declined and had disappeared completely by the fifth day. In tolerance studies, heroin (0.032–0.5 mg/kg, i.m.) and morphine (1–16 mg/kg, i.m.) were injected cumulatively each day for three consecutive days. These drugs suppressed f and Veto nearly the same extent on day 3 as they had on day 1 of administration. These results suggest that dependence to morphine and heroin can be measured under conditions of acute 1 to 3 day administration conditions in primates using f and Veas reliable and quantitative indicators of opioid withdrawal. Under these conditions, tolerance does not occur.
