Whole-Brain Perfusion CT Performed with a Prototype 256-Detector Row CT System: Initial Experience
Whole-Brain Perfusion CT Performed with a Prototype 256-Detector Row CT System: Initial Experience
复制标题
DOI：
10.1148/radiol.2501071809
复制
发表时间：
2009-01-01
期刊：
影响因子：
19.7
通讯作者：
Murphy, Kieran J.
中科院分区：
文献类型：
--
作者：
Murayama, Kazuhiro;Katada, Kazuhiro;Murphy, Kieran J.
目的：初步评估使用原型 256 排 CT 系统在覆盖整个大脑的扩展范围内进行全脑灌注计算机断层扫描 (CT) 来评估缺血性脑血管疾病的可行性和潜在诊断效用。 材料和方法：获得机构审查委员会批准并获得知情同意。采用全脑灌注 CT 回顾性评估 10 名受试者（6 名男性，4 名女性；平均年龄 64.3 岁）的 11 例颅内或颅外狭窄病例。三位读者独立评估灌注 CT 数据。灌注CT的诊断性能通过用于评估三个因素的三点量表进行视觉评估。通过配对 t 检验评估在基底节水平获得的四张轴向灌注 CT 图像（以下称为四部分图像）与全脑灌注 CT 图像之间的差异。在 4 名受试者中，灌注 CT 与单光子发射计算机断层扫描 (SPECT) 之间的间隔为 1-17 天（平均 10.3 天）。采用Spearman相关系数评估灌注CT表现与SPECT表现的相关性。结果：显示三维灌注CT图像和轴位、冠状位、矢状位全脑灌注CT图像，评估缺血程度。全脑图像的平均视觉评估分数显着高于四部分图像（4.27 +/- 0.76 [标准差] vs 2.55 +/- 0.87）。灌注CT(x)和SPECT(y)扫描的缺血病灶相对正常区域的脑血流比值呈显着正相关(R-2=0.76,y=0.44x+0.37,P
Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256-detector row CT system over an extended range covering the entire brain to assess ischemic cerebrovascular disease.Materials and Methods: Institutional review board approval and informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) with intra- or extracranial stenosis were retrospectively evaluated with whole-brain perfusion CT. Three readers independently evaluated perfusion CT data. The diagnostic performance of perfusion CT was visually evaluated with a three-point scale used to assess three factors. Differences between four axial perfusion CT images obtained at the basal ganglia level (hereafter, four-section images) and whole-brain perfusion CT images were assessed with the paired t test. In four subjects, the interval between perfusion CT and single photon emission computed tomography (SPECT) was 1-17 days (mean, 10.3 days). Correlation between perfusion CT findings and SPECT findings was assessed with the Spearman correlation coefficient.Results: Three-dimensional perfusion CT images and axial, coronal, and sagittal whole-brain perfusion CT images were displayed, and the extent of ischemia was assessed. Mean visual evaluation scores were significantly higher for whole-brain images than for four-section images (4.27 +/- 0.76 [standard deviation] vs 2.55 +/- 0.87). The cerebral blood flow ratios of the ischemic lesions relative to normal regions scanned with perfusion CT (x) and SPECT (y) showed a significant positive correlation (R-2 = 0.76, y = 0.44x + 0.37, P