Focal lymphocytic infiltration in the adrenal cortex of the elderly: immunohistological analysis of infiltrating lymphocytes.
Focal lymphocytic infiltration in the adrenal cortex of the elderly: immunohistological analysis of infiltrating lymphocytes.
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老年人肾上腺皮质局灶性淋巴细胞浸润：浸润淋巴细胞的免疫组织学分析。
DOI：
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发表时间：
1989
影响因子：
4.6
通讯作者：
K. Hirokawa
中科院分区：
文献类型：
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作者：
Y. Hayashi;T. Hiyoshi;T. Takemura;C. Kurashima;K. Hirokawa
对青年和老年人尸检标本中肾上腺皮质单个核细胞的浸润率进行了检测，并用免疫组织化学方法对浸润性单个核细胞进行了鉴定。组织学上，在174例年龄大于60岁的尸检病例中，110例(63.2%)在肾上腺皮质内有不同程度的单核细胞浸润，而在54例年龄小于49岁的年轻对照组中，这种病变的发生率较低(7.4%)。此外，肾上腺皮质的严重浸润性病变常见于70岁以上的老年人。免疫组织化学研究显示，浸润性单个核细胞主要由CD3+T细胞组成。CD3+T细胞主要表达CD4，CD8+T细胞数量较少。此外，通过白细胞介素2受体的表达判断，相当大比例的CD4+T细胞被激活。这些结果表明，老年人肾上腺皮质中T淋巴细胞的浸润可能是器官特异性自身免疫性肾上腺炎的临床前表现，其基础是与衰老过程相关的自身免疫。
The incidence of mononuclear cell infiltration in the adrenal cortex was examined in autopsy cases of young and old subjects, and the infiltrating mononuclear cells were immunohistologically characterized by monoclonal antibodies. Histologically, 110 of 174 autopsy cases of persons greater than 60 years (63.2%) were shown to have mononuclear cell infiltration of varying degree within the adrenal cortex, whereas such a lesion was observed in lesser incidence (7.4%) in the 54 younger, control subjects aged less than 49 years. In addition, severely infiltrating lesions in the adrenal cortex were found frequently in the elderly greater than 70 years. Immunohistochemical study revealed that the infiltrating mononuclear cells were mainly composed of CD3+ T cells. The major proportion of CD3+ T cells expressed CD4, whereas CD8+ T cells were less in number. Moreover, a considerable proportion of CD4+ T cells was activated as judged by interleukin 2 receptor expression. These findings indicate that T lymphocytes infiltration in aged human adrenal cortex may represent a pre-clinical manifestation of organ-specific autoimmune adrenalitis which is based on autoimmunity associated with ageing process.