Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease
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DOI：
10.1097/fpc.0b013e3283485eb2
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发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Wang, Dao Wen
中科院分区：
文献类型：
--
作者：
Xu, Yujun;Ding, Hu;Wang, Dao Wen
目的细胞色素P450 2J2(CYP2J2)和环氧化物水解酶2(EPHX2)参与了环氧二十碳三烯酸的生成或降解，其常见的基因多态性可能决定心血管疾病的易感性。为了更准确地估计它们之间的关系，我们进行了一项病例对照研究和荟萃分析，以评估CYP2J2和EPHX2基因变异与冠状动脉疾病(CAD)风险的可能关联。方法在1344例病例和1267名种族和地理匹配的对照中，研究了CYP2J2和EPHX2的4个单核苷酸多态和5个EPHX2单核苷酸多态与冠心病的关联。为了进一步证实G-50T和R287Q两个功能变异在冠心病发病中的作用，我们在2010年6月之前进行了包括7个G-50T多态和6个R287Q多态的荟萃分析。结果无论是单基因座分析还是基于单倍型的分析，均未发现这两个基因的常见多态与冠心病的相关性。此外，在我们的荟萃分析中，未发现这两个功能变异与冠心病发病风险之间的关联。结论本病例对照研究和荟萃分析提示，CYP2J2 G-50T和EPHX2 R287Q基因与冠心病的发病风险无关。药物遗传学和基因组学21：489-494(C)2011 Wolters Kluwer Health垂直条Lippincott Williams&Wilkins。
Objective Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease. To derive a more precise estimation of their relationship, we undertook a case-control study as well as a meta-analysis to assess possible associations of coronary artery disease (CAD) risk with CYP2J2 and EPHX2 genetic variations.Methods Associations among four single nucleotide polymorphisms in CYP2J2 and five in EPHX2 with CAD were examined in a total of 1344 cases and 1267 ethnically and geographically matched controls. To further confirm the effect of two functional variants (G-50T and R287Q) in the development of CAD, we conducted a meta-analysis including seven studies on G-50T polymorphism and six studies on R287Q polymorphism before June 2010.Results No significant association between common polymorphisms within these two genes and CAD was observed in our sample, either using methods of single-locus analysis or haplotype-based analysis. In addition, no association was detected in our meta-analysis between these two functional variants and the risk of developing CAD.Conclusion This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing CAD. Pharmacogenetics and Genomics 21: 489-494 (c) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.