Protein kinase C and cell cycle
Protein kinase C and cell cycle
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发表时间：
2001
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通讯作者：
J. Shao
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作者：
J. Shao
Protein kinase C(PKC) is involved in diverse cellular function. Recently, that PKC on cell cycle control has began to emerge in both yeast and mammals,which suggest that PKC is a conserved regulator of cell cycle in evolution progression. PKC regulate cell cycle at two sites, G1 and G2/M transition. During G1 progression, PKC has different effects on early and later phases, and overall effect is to inhibit cell cycle at mid to late G1 through blocking phosphorylation of tumor suppressor retinoblastoma(Rb) protein. Furthermore, PKC reduce activity of cyclin-dependent kinase CDK2, inhibit expression of cyclin E and A and augment produce of cyclin-dependent inhibitors, p21WAF1 and p27KIP1; During G2/M boundary, PKC mainly inhibit activity of Cdc2 and prevent cell from entering M. In this paper, we will review PKC on cell cycle control.
