Microchimerism in autoimmune disease: more questions than answers?
Microchimerism in autoimmune disease: more questions than answers?
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DOI：
10.1016/s1568-9972(02)00149-0
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发表时间：
2003-05-01
影响因子：
13.6
通讯作者：
Nelson, JL
中科院分区：
文献类型：
--
作者：
Lambert, N;Nelson, JL
最近的研究表明，在怀孕期间，胎儿和母亲之间会发生细胞运输，并且在怀孕后的几年里，胎儿细胞的低数量通常会在母体循环中持续存在。微嵌合是指将一个人的少量细胞或DNA植入另一个人体内。自身免疫性疾病在妇女中更为常见，并且往往在生育年龄后发病率增加。慢性移植物抗宿主病是一种医源性嵌合形式，与一些自身免疫性疾病相似，供体和宿主的HLA关系至关重要。综合考虑，这些观察结果导致了宿主和非宿主细胞的微嵌合和HLA关系参与自身免疫性疾病的假设。这一假设适用于没有怀孕的男性、儿童和女性，因为还有其他来源的微嵌合，包括来自双胞胎、母亲或输血。微嵌合现已在许多不同的疾病中进行了研究，一些结果支持在疾病发病机制中的潜在作用。然而，在受非自身免疫性疾病影响的器官中也发现了胎儿和母体的微嵌合现象。此外，在健康个体的外周血中经常检测到微嵌合现象，这引发了一个有趣的问题：这些细胞是怀孕的简单残余，还是它们也可能对宿主有益。(C) 2003 Elsevier Science B.V.版权所有
Recent studies indicate cell traffic occurs between the fetus and mother during pregnancy and that low numbers of fetal cells commonly persist in the maternal circulation for years thereafter. Microchimerism refers to a small number of cells or DNA from one individual harbored in another individual. Autoimmune diseases are more common among women and often increase in incidence following reproductive years. Chronic graft vs. host disease is an iatrogenic form of chimerism with similarities to some autoimmune diseases for which the HLA relationship of donor and host are of central importance. When considered together, these observations led to the hypothesis that microchimerism and HLA relationships of host and non-host cells are involved in autoimmune disease. The hypothesis is applicable to men, children and women without pregnancies because there are other sources of microchimerism, including from a twin, the mother or a blood transfusion. Microchimerism has now been investigated in a number of different diseases with some results supporting a potential role in disease pathogenesis. However, fetal and maternal microchimerism are also found in organs affected by non-autoimmune conditions. Moreover,microchimerism is commonly detected in the peripheral blood of healthy individuals raising the intriguing question of whether these cells are simple remnants of pregnancy or whether they might also have beneficial effects for the host. (C) 2003 Elsevier Science B.V. All rights reserved.