Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
复制标题
DOI：
10.1016/s0092-8674(02)01279-5
复制
发表时间：
2003-02-07
期刊：
影响因子：
64.5
通讯作者：
Mann, RS
中科院分区：
文献类型：
--
作者：
Culi, J;Mann, RS
细胞表面受体通过分泌途径的成熟通常需要分子伴侣，这些分子伴侣有助于蛋白质折叠以及从一个细胞器运输到另一个细胞器。在此我们描述boca，它是黑腹果蝇中一个进化上保守的基因，其编码一种内质网蛋白，该蛋白是低密度脂蛋白受体家族（LDLRs）成员的细胞内运输所特需的。果蝇中的两种LDLR，即对无翅信号转导所必需的Arrow和在卵子发生过程中对卵黄蛋白摄取所必需的Yolkless，都需要boca的功能。因此，boca是无翅信号通路的一个重要组成部分，但更普遍地是多个LDL受体家族成员活动所必需的。
The maturation of cell surface receptors through the secretory pathway often requires chaperones that aid in protein folding and trafficking from one organelle to another. Here we describe boca, an evolutionarily conserved gene in Drosophila melanogaster, which encodes an endoplasmic reticulum protein that is specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs). Two LDLRs in flies, Arrow, which is required for Wingless signal transduction, and Yolkless, which is required for yolk protein uptake during oogenesis, both require boca function. Consequently, boca is an essential component of the Wingless pathway but is more generally required for the activities of multiple LDL receptor family members.