The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused rat liver.
The role of selenium in the secretion of very-low-density lipoprotein in the isolated perfused rat liver.
复制标题
硒在离体灌注大鼠肝脏分泌极低密度脂蛋白中的作用。
DOI：
10.1042/bj2790741
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Stone,WL
中科院分区：
文献类型：
--
作者：
Scott,RL;Kheshti,A;Heimberg,M;Wilcox,HG;Stone,WL
采用循环肝灌流系统研究了硒对肝脏分泌极低密度脂蛋白（VLDL）的影响。从大鼠肝脏灌流液喂养的硒缺乏的饮食纳入约50%以上的[1- 14 C]油酸三酰甘油（TG）和胆固醇酯（ChoEs）比从大鼠肝脏灌流液喂养的硒补充饮食。同样，与补硒饮食的大鼠肝脏相比，补硒饮食的大鼠肝脏分泌更多的VLDL，并将约60%的[1- 14 C]油酸纳入VLDL TG和ChoE中。低硒组大鼠肝脏灌流液脂肪酸氧化也明显降低。我们得出结论，硒是脂蛋白代谢的一个有效的调制器。硒缺乏的主要作用似乎是减少脂肪酸氧化和刺激脂肪酸酯化，导致VLDL TG和ChoEs的形成和分泌增加。
A recirculating liver perfusion system was used to study the effects of dietary selenium (Se) on the hepatic secretion of very-low-density lipoprotein (VLDL). The perfusate from livers of rats fed on a Se-deficient diet incorporated about 50% more [1-14C]oleic acid into triacylglycerol (TG) and cholesteryl esters (ChoEs) than did the perfusate from livers of rats fed on a Se-supplemented diet. Similarly, livers from rats fed the Se-deficient diet secreted more VLDL and incorporated about 60% more [1-14C]oleic acid into VLDL TG and ChoEs than did livers from rats fed the Se-supplemented diet. The liver perfusate from rats in the Se-deficient group also showed significantly decreased fatty acid oxidation. We conclude that Se is a potent modulator of lipoprotein metabolism. A primary action of Se deficiency appears to be a decrease in fatty acid oxidation and a stimulation of fatty acid esterification, leading to increased VLDL TG and ChoEs formation and secretion.