Exhaled nitric oxide in pregnant healthy and asthmatic women.
Exhaled nitric oxide in pregnant healthy and asthmatic women.
复制标题
健康孕妇和哮喘妇女呼出的一氧化氮。
DOI：
10.3109/02770900903090004
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
I. Horváth
中科院分区：
文献类型：
--
作者：
L. Tamási;A. Bohács;A. Bikov;C. Andorka;J. Rigó;G. Losonczy;I. Horváth
背景
呼出部分一氧化氮(FE(NO))的测定有助于监测哮喘患者的呼吸道炎症反应。哮喘是妊娠期最常见的疾病之一，FE(NO)可能有助于监测妊娠期哮喘。然而，在健康妊娠期间，由于血管一氧化氮的产生，FE(NO)可能会发生一些生理变化。到目前为止，还没有研究评估妊娠哮喘患者的FE(NO)水平。
客观化
我们的目的是评估FE(NO)测量在妊娠哮喘妇女中的可能用途和重复性。我们比较了四组受试者的FE(NO)浓度：健康的未怀孕和怀孕的女性和哮喘未怀孕和怀孕的患者。我们还探讨了FE(NO)值与妊娠哮喘患者哮喘控制水平的关系。
方法
共有102名女性受试者(35名健康的未怀孕女性和27名健康的怀孕女性；20名未怀孕的和20名怀孕的哮喘女性)参加了这项横断面研究。在每个受试者中使用基于电化学传感器的装置(Niox Mino，Aercriine，Solna，瑞典)进行两次FE(NO)测量。数据以带范围的中位数形式给出。
结果
孕妇和非孕者FE(NO)测定的重复性相似。Fe(NO)水平在健康孕妇和未怀孕受试者之间没有显著差异(16.0[8，31]ppb对16.0[9，35]ppb)。哮喘患者Fe(NO)水平显著高于健康女性(非妊娠哮喘患者：38[9，54]ppb，p<；0.001 vs健康未孕患者；妊娠哮喘患者：28[10，56]ppb；p<；0.05 vs健康孕妇)。
结论
Fe(NO)水平不受健康妊娠的影响。妊娠期哮喘患者FE(NO)水平较正常妊娠者升高，且与哮喘控制水平相关。还需要进一步的研究来评估FE(NO)测量在该患者组中监测哮喘的使用情况。
BACKGROUND
Measurement of fractioned exhaled nitric oxide (FE(NO)) is useful for monitoring airway inflammation in asthma. Asthma is one of the most common diseases complicating pregnancy, and FE(NO) may be helpful for monitoring asthma in pregnancy. However, some physiological alterations of FE(NO) may be expected during healthy pregnancy due to vascular nitric oxide production. Until now no study assessed the level of FE(NO) in asthmatic pregnant patients.
OBJECTIVE
We aimed to assess the possible use and reproducibility of FE(NO) measurements in pregnant asthmatic women. We compared FE(NO) concentrations between four groups of subjects: healthy nonpregnant and pregnant females and asthmatic nonpregnant and pregnant patients. We also investigated the relationship between FE(NO) values and the level of asthma control in pregnant asthmatic patients.
METHODS
A total of 102 female subjects (35 healthy nonpregnant and 27 healthy pregnant females; 20 nonpregnant and 20 pregnant asthmatic women) were included in this cross-sectional study. Two FE(NO) measurements were performed in each subject using an electrochemical sensor based device (NIOX MINO, Aerocrine, Solna, Sweden). Data are given as median with range.
RESULTS
The repeatability of FE(NO) measurement was similar in pregnant and nonpregnant subjects. FE(NO) levels did not differ significantly between healthy pregnant versus nonpregnant subjects (16.0 [8, 31] vs. 16.0 [9, 35] ppb). FE(NO) levels were significantly increased in asthmatic women compared to healthy females (nonpregnant asthmatics: 38 [9, 54] ppb, p < 0.001 vs. healthy nonpregnant; pregnant asthmatic patients: 28 [10, 56] ppb; p < 0.05 vs. healthy pregnant).
CONCLUSIONS
FE(NO) level is not influenced by healthy pregnancy. In pregnant asthmatic patients FE(NO) level is elevated compared to healthy pregnant subjects and correlates with the level of asthma control. Further studies are required to assess the use of FE(NO) measurement to monitor asthma in this patient group.