Detecting Pairwise Correlations in Spike Trains: An Objective Comparison of Methods and Application to the Study of Retinal Waves
Detecting Pairwise Correlations in Spike Trains: An Objective Comparison of Methods and Application to the Study of Retinal Waves
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DOI：
10.1523/jneurosci.2767-14.2014
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发表时间：
2014-10-22
影响因子：
5.3
通讯作者：
Eglen, Stephen J.
中科院分区：
文献类型：
--
作者：
Cutts, Catherine S.;Eglen, Stephen J.
神经元峰值时间的相关性被认为是许多神经系统处理的关键。人们提出了许多方法来总结这些相关性，其中相关指数被广泛使用，是自发视网膜活动研究的标准。我们证明了这个测度有两个不希望的性质：它在上面是无界的，并且被射速混淆。我们列出了衡量公平量化和比较相关性所需的属性，并提出了一种新的衡量相关性的方法——峰值时间平铺系数。该系数、相关指数和其他33个尖峰时间相关度量在合成和实验数据上进行了所需性能的盲目测试。在此基础上，我们提出了一个度量（尖峰时间平铺系数）来代替相关指标。为了证明这一措施的好处，我们重新分析了七个关键研究的数据，这些研究之前使用相关指数来调查自发活动的性质。我们重新分析了β 2（KO）和β 2（TG）突变体、缺乏连接蛋白异构体的突变体的数据，以及野生型和β 2（KO）相关性的年龄依赖性变化。使用提出的测量方法重新分析数据可以显著改变结论。它可以更好地量化相关性，从而更好地从数据中进行推断。我们希望所提出的措施将有广泛的应用，并将有助于阐明活性在视网膜位图形成中的作用。
Correlations in neuronal spike times are thought to be key to processing in many neural systems. Many measures have been proposed to summarize these correlations and of these the correlation index is widely used and is the standard in studies of spontaneous retinal activity. We show that this measure has two undesirable properties: it is unbounded above and confounded by firing rate. We list properties needed for a measure to fairly quantify and compare correlations and we propose a novel measure of correlation-the spike time tiling coefficient. This coefficient, the correlation index, and 33 other measures of correlation of spike times are blindly tested for the required properties on synthetic and experimental data. Based on this, we propose a measure (the spike time tiling coefficient) to replace the correlation index. To demonstrate the benefits of this measure, we reanalyze data from seven key studies, which previously used the correlation index to investigate the nature of spontaneous activity. We reanalyze data from beta 2(KO) and beta 2(TG) mutants, mutants lacking connexin isoforms, and also the age-dependent changes in wild-type and beta 2(KO) correlations. Reanalysis of the data using the proposed measure can significantly change the conclusions. It leads to better quantification of correlations and therefore better inference from the data. We hope that the proposed measure will have wide applications, and will help clarify the role of activity in retinotopic map formation.