Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system
Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system
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DOI：
10.1093/ajcn/80.6.1717s
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发表时间：
2004-12-01
影响因子：
7.1
通讯作者：
Wittke, A
中科院分区：
文献类型：
--
作者：
Cantorna, MT;Zhu, Y;Wittke, A
维生素D是一种重要的免疫系统调节剂。维生素D的活性形式，1，25-二羟基维生素D-3 [1，25（OH）（2）D-3]，已被证明可以抑制自身免疫性疾病的发展，包括炎症性肠病（IBD）。特别是，其他免疫系统介导的疾病（实验性哮喘）和对感染性生物体的免疫力不受1，25（OH）（2）D-3治疗的影响。维生素D缺乏对各种免疫系统功能也有类似的矛盾影响。维生素D和维生素D受体（VDR）缺乏导致IBD加速。实验性哮喘不受1，25（OH）（2）D-3治疗的影响，并且在VDR缺陷小鼠中不太严重。维生素D是免疫系统的选择性调节剂，1，25（OH）（2）D-3治疗、维生素D缺乏症或VDR缺乏症的结果取决于免疫反应的性质（例如，感染性疾病、哮喘或自身免疫性疾病）。决定维生素D状态对免疫功能影响的另一个因素是膳食钙。膳食钙对IBD严重程度有独立影响。低钙饮食的维生素D缺乏小鼠发展为最严重的IBD，1，25（OH）（2）D-3治疗低钙饮食的小鼠改善IBD症状。然而，当钙浓度高且给予1，25（OH）（2）D-3时，观察到IBD的最佳结果。免疫反应的类型和宿主的钙状态决定了维生素D状态和1，25（OH）（2）D-3对免疫力的影响。
Vitamin D is an important immune system regulator. The active form of vitamin D, 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], has been shown to inhibit the development of autoimmune diseases, including inflammatory bowel disease (IBD). Paradoxically, other immune system-mediated diseases (experimental asthma) and immunity to infectious organisms were unaffected by 1,25(OH)(2)D-3 treatment. There are similar paradoxical effects of vitamin D deficiency on various immune system functions. Vitamin D and vitamin D receptor (VDR) deficiency resulted in accelerated IBD. Experimental asthma was unaffected by 1,25(OH)(2)D-3 treatment and was less severe among VDR-deficient mice. Vitamin D is a selective regulator of the immune system, and the outcome of 1,25(OH)(2)D-3 treatment, vitamin D deficiency, or VDR deficiency depends on the nature of the immune response (eg, infectious disease, asthma, or autoimmune disease). An additional factor that determines the effect of vitamin D status on immune function is dietary calcium. Dietary calcium has independent effects on IBD severity. Vitamin D-deficient mice on low-calcium diets developed the most severe IBD, and 1,25(OH)(2)D-3 treatment of mice on low-calcium diets improved IBD symptoms. However, the best results for IBD were observed when the calcium concentration was high and 1,25(OH)(2)D-3 was administered. Both the type of immune response and the calcium status of the host determine the effects of vitamin D status and 1,25(OH)(2)D-3 on immunity.