Diverse and dynamic functions of the Sir silencing complex
Diverse and dynamic functions of the Sir silencing complex
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DOI：
10.1038/15458
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发表时间：
1999-11-01
期刊：
影响因子：
30.8
通讯作者：
Guarente, L
中科院分区：
文献类型：
--
作者：
Guarente, L
酵母 Sir 蛋白复合物与转录沉默和重组抑制有关。 Sir 复合体在端粒、沉默交配型基因座和核糖体 DNA 上创建结构化染色体结构域，以调用这些功能状态。对 Sir 蛋白功能的机制了解涉及酵母中的一系列活动，包括 DNA 双链断裂的修复、有丝分裂细胞周期的调节、减数分裂和衰老。我推测 Sir 蛋白可能能够对染色质和其他底物进行酶促修饰，从而使其能够执行广泛的细胞功能。
The yeast Sir protein complex has been implicated in transcriptional silencing and suppression of recombination. The Sir complex creates structured chromosomal domains at telomeres, silent mating-type loci and ribosomal DNA to invoke these functional states. Mechanistic insights into the function of Sir proteins implicate a range of activities in yeast, including repair of DNA double-strand breaks, regulation of the mitotic cell cycle, meiosis and ageing. I speculate that the Sir proteins may be capable of enzymatic modification of chromatin and other substrates, which enables them to carry out a broad range of cellular functions.