The evolving biology of Mycobacterium tuberculosis drug resistance.
The evolving biology of Mycobacterium tuberculosis drug resistance.
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DOI：
10.3389/fcimb.2022.1027394
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
由结核分枝杆菌（Mtb）引起的结核病是一种古老的疾病，仍然是传染性死亡的主要原因。结核分枝杆菌已经进化出了对每一种抗生素方案的耐药性，极大地使治疗复杂化，降低了治愈率，并威胁到世界部分地区的结核病控制。随着技术的进步，我们对抗菌素耐药性的理解有所提高，我们对这一现象的模型也有所发展。在这篇综述中，我们重点介绍了支持结核分枝杆菌耐药进化的最新模型的最新研究进展。我们强调了药物耐受性对耐药性的贡献，以及异质性对耐受性的影响。只要需要治疗结核病的药物，耐药性可能仍然是一个问题。然而，随着技术推动新的见解和对新开发资源的谨慎管理，抗菌素耐药性不必像几十年来那样继续威胁全球防治结核病的进展。
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb) is an ancient disease that has remained a leading cause of infectious death. Mtb has evolved drug resistance to every antibiotic regimen ever introduced, greatly complicating treatment, lowering rates of cure and menacing TB control in parts of the world. As technology has advanced, our understanding of antimicrobial resistance has improved, and our models of the phenomenon have evolved. In this review, we focus on recent research progress that supports an updated model for the evolution of drug resistance in Mtb. We highlight the contribution of drug tolerance on the path to resistance, and the influence of heterogeneity on tolerance. Resistance is likely to remain an issue for as long as drugs are needed to treat TB. However, with technology driving new insights and careful management of newly developed resources, antimicrobial resistance need not continue to threaten global progress against TB, as it has done for decades.
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影响因子：
6.7
作者：
Carey AF;Rock JM;Krieger IV;Chase MR;Fernandez-Suarez M;Gagneux S;Sacchettini JC;Ioerger TR;Fortune SM
通讯作者：
Fortune SM
影响因子：
10.7
作者：
Castro, Rhastin A. D.;Ross, Amanda;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
影响因子：
5.2
作者：
Brandis, Gerrit;Hughes, Diarmaid
通讯作者：
Hughes, Diarmaid
由巨噬细胞诱导的外排机制介导的复制分枝杆菌的药物耐受性。
影响因子：
64.5
作者：
Adams KN;Takaki K;Connolly LE;Wiedenhoft H;Winglee K;Humbert O;Edelstein PH;Cosma CL;Ramakrishnan L
通讯作者：
Ramakrishnan L
影响因子：
56.9
作者：
Andries, K;Verhasselt, P;Jarlier, V
通讯作者：
Jarlier, V