State and neuronal class-dependent reconfiguration in the avian song system.
State and neuronal class-dependent reconfiguration in the avian song system.
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DOI：
10.1152/jn.00655.2002
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发表时间：
2003-03
影响因子：
2.5
通讯作者：
Peter L. Rauske;Stephen D. Shea;D. Margoliash
中科院分区：
文献类型：
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作者：
Peter L. Rauske;Stephen D. Shea;D. Margoliash
感觉系统可以通过状态依赖性变化来适应行为要求。在斑胸草雀的前脑鸣唱系统核HVc中，状态依赖的听觉反应已被描述在多单位记录中。在这里，我们报告的不同HVc神经元类的活动的行为状态依赖的变化。在麻醉的斑胸草雀中，通过电刺激HVc的靶核，即原纹状体的健壮核和X区，鉴定HVc投射神经元。投射神经元和两类假定的interneurons可以区分的基础上的细胞外锋电位波形，与前两个因素的主成分分析占81%的变化，在穗形态测量值。尖峰宽度是区分神经元类别的最佳单一变量。假定的中间神经元有更高的自发放电率和对歌曲的反应比投射神经元，后者对歌曲的自发放电率和阶段性反应极低。记录从HVc在行为动物占主导地位的两类假定的interneurons。这两类在睡眠期间表现出强烈的，选择性的和时间上相似的听觉反应，但只有一类中间神经元在清醒时可靠地维持听觉反应。这些反应比睡眠中看到的反应更弱，选择性更低。HVc听觉反应在清醒的斑胸草雀被限制到某些类别的神经元的观察可能有助于解释以前的多单元的结果，建议几乎完全抑制HVc听觉反应在清醒的鸟类。我们建议，不同的HVc神经元亚群的行为状态的异质性影响，让HVc参与在歌曲制作，同种歌曲识别，并可能在睡眠中的记忆巩固的多个角色。
Sensory systems may adapt to behavioral requirements through state-dependent changes. In the forebrain song-system nucleus HVc of zebra finches, state-dependent auditory responses have been described in multiunit recordings. Here we report on behavioral state-dependent changes in the activity of distinct HVc neuronal classes. HVc projection neurons were identified by electrically stimulating HVc's target nuclei, the robust nucleus of the archistriatum and Area X, in anesthetized zebra finches. Projection neurons and two classes of putative interneurons could be distinguished on the basis of extracellular spike waveforms, with the first two factors of a principal components analysis accounting for 81% of the variance in spike morphometric values. Spike width was the best single variable for distinguishing among the neuronal classes. Putative interneurons had much higher firing rates spontaneously and in response to song than did projection neurons, which had extremely low spontaneous rates and phasic responses to song. Recordings from HVc in behaving animals were dominated by the two classes of putative interneurons. Both classes showed strong, selective, and temporally similar auditory responses during sleep, but only one class of interneurons reliably maintained auditory responses on waking. These responses were weaker and less selective than those seen during sleep. The observation that HVc auditory responsiveness in awake zebra finches is restricted to some classes of neurons may help explain prior multiunit results that suggested nearly complete suppression of HVc auditory responses in awake birds. We propose that the heterogeneous effects of behavioral state on distinct subpopulations of HVc neurons allow HVc to participate in multiple roles during song production, conspecific song recognition, and possibly memory consolidation during sleep.