Target cell limited and immune control models of HIV infection: A comparison
Target cell limited and immune control models of HIV infection: A comparison
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DOI：
10.1006/jtbi.1997.0548
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发表时间：
1998-02-07
影响因子：
2
通讯作者：
Perelson, AS
中科院分区：
文献类型：
--
作者：
De Boer, RJ;Perelson, AS
我们开发了HIV-1感染的临床潜伏期阶段的各种数学模型，假设HIV-1感染受到HIV可以感染的细胞的可用性或特定的抗HIV细胞免疫反应的限制。前一种模型我们称之为“目标细胞有限”。通过相平面分析比较，我们发现它们都属于一类捕食模型。在靶细胞限制模型中，病毒是捕食者，以靶细胞猎物为食，而在免疫控制模型中，病毒是被免疫反应捕食者控制的猎物。由于这两类模型都是捕食者-食饵模型，它们在大多数情况下的行为相似。我们发现，这两种类型的模型可以解释疾病进展的一般情况，其中CD 4 T细胞计数缓慢下降，病毒载量缓慢增加。此外，我们发现，这两种类型的模型可以充分描述临床观察到的变化，血浆HIV-1的RNA负载在响应逆转录病毒治疗。(C)出版社：Academic Press Limited。
We develop various mathematical models of the clinical latency stage of HIV-I infection assuming that HIV-1 infection is limited either by the availability of cells that HIV can infect or by a specific anti-HIV cellular immune response. The former models we call "target-cell-limited". Comparing the models by phase plane analysis we find that they all belong to the class of predator-prey models. In the target-cell-limited models the virus is a predator feeding upon target cell prey, while in the immune-control models the virus is a prey that is controlled by an immune response predator. Because both classes of models are of predator-prey type they behave similarly in most circumstances. We find that both types of model can account for the generic picture of disease progression in which the CD4 T cell count slowly decreases and the viral load slowly increases. Additionally, we find that both types of models can adequately describe the clinically observed changes in the plasma HIV-I RNA loads in response to retroviral therapies. (C) 1998 Academic Press Limited.