Human RecQ helicases in DNA repair, recombination, and replication.
Human RecQ helicases in DNA repair, recombination, and replication.
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DOI：
10.1146/annurev-biochem-060713-035428
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发表时间：
2014
影响因子：
16.6
通讯作者：
Bohr VA
中科院分区：
文献类型：
--
作者：
Croteau DL;Popuri V;Opresko PL;Bohr VA
RecQ解旋酶是一个重要的基因组监视蛋白家族，从细菌到人类都是保守的。五种人类RecQ解旋酶中的每一种都在基因组的维持和稳定性中起着关键作用，RecQ蛋白家族成员通常被称为基因组的监护人。BLM、WRN和RECQL 4的缺陷与不同的可遗传人类疾病综合征有关，这一事实强调了这些蛋白质在细胞内稳态中的重要性。每个人类RecQ解旋酶都有一组独特的蛋白质相互作用伴侣，这些相互作用决定了其在基因组维护中的专门功能，包括DNA修复，重组，复制和转录。人类RecQ解旋酶也彼此相互作用，并且这些相互作用对酶功能具有显著影响。该领域未来的研究目标包括更好地了解人类RecQ解旋酶之间的分工，并了解人类RecQ解旋酶如何协作和合作以增强基因组稳定性。
RecQ helicases are an important family of genome surveillance proteins conserved from bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome maintenance and stability, and the RecQ protein family members are often referred to as guardians of the genome. The importance of these proteins in cellular homeostasis is underscored by the fact that defects in BLM, WRN, and RECQL4 are linked to distinct heritable human disease syndromes. Each human RecQ helicase has a unique set of protein-interacting partners, and these interactions dictate its specialized functions in genome maintenance, including DNA repair, recombination, replication, and transcription. Human RecQ helicases also interact with each other, and these interactions have significant impact on enzyme function. Future research goals in this field include a better understanding of the division of labor among the human RecQ helicases and learning how human RecQ helicases collaborate and cooperate to enhance genome stability.