EVIDENCE FOR TRANSIENT LINKING OF ATRIAL EXCITATION DURING ATRIAL-FIBRILLATION IN HUMANS
EVIDENCE FOR TRANSIENT LINKING OF ATRIAL EXCITATION DURING ATRIAL-FIBRILLATION IN HUMANS
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DOI：
10.1161/01.cir.86.2.375
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发表时间：
1992-08-01
期刊：
影响因子：
37.8
通讯作者：
SWIRYN, S
中科院分区：
文献类型：
--
作者：
GERSTENFELD, EP;SAHAKIAN, AV;SWIRYN, S
背景。心房颤动通常被认为是循环小波的“随机”模式。然而，局部心房激动应该受到持续的解剖结构和上次激动后不应期尾部后退的影响。波前遵循先前激励路径的一般趋势被称为“链接”。我们检查了心房颤动期间记录的心房内电图，以寻找关联的证据。方法和结果。使用正交导管记录了 15 名患者两分钟的心房颤动。我们之前已经证明该导管可用于检测局部心房激动方向的变化。计算每个电描记图的平均向量。通过计算两个连续电描记图之间的最小角度 (theta) 的余弦 (cos)，可以在 1 到 -1 的范围内量化两个连续电描记图矢量方向的相似性。指向相同或相反方向的两个向量分别具有 cos(theta)=1 或 -1。对于整个患者组，平均 cos(theta) 显着大于 0（平均值为 0.36；p
Background. Atrial fibrillation is usually thought of as a "random" pattern of circulating wavelets. However, local atrial activation should be influenced by the constant anatomy and receding tail of refractoriness from the previous activation. The general tendency for wave fronts to follow paths of previous excitation has been termed "linking." We examined intra-atrial electrograms recorded during atrial fibrillation for evidence of linking.Methods and Results. Two minutes of atrial fibrillation were recorded in 15 patients with an orthogonal catheter. We have previously demonstrated that this catheter can be used to detect changes in the direction of local atrial activation. A mean vector was calculated for each electrogram. The similarity of the direction of the vectors from two consecutive electrograms can be quantified on a scale of 1 to -1 by calculating the cosine (cos) of the smallest angle (theta) between them. Two vectors pointing in the same or opposite directions then have cos(theta)=1 or -1, respectively. For the entire group of patients, mean cos(theta) was significantly greater than 0 (mean, 0.36; p