Occupational categories at risk for Parkinson's disease
Occupational categories at risk for Parkinson's disease
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DOI：
10.1002/ajim.1055
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发表时间：
2001-06-01
影响因子：
3.5
通讯作者：
Gorell, JM
中科院分区：
文献类型：
--
作者：
Kirkey, KL;Johnson, CC;Gorell, JM
背景帕金森病 (PD) 的病因被认为与环境因素密切相关，但相对较少的研究调查了职业与疾病之间的潜在关联。方法在一项基于人群的病例对照研究中，我们收集了所有研究参与者（144 名病例和 464 名对照受试者）的全面职业史。结果卡方分析显示，从事农业职业会增加估计的帕金森病风险（OR = 1.74；95% CI = 0.85， 3.60）。相比之下，曾经从事服务职业的经历与 PD 风险呈负相关（OR = 0.69；95% CI = 0.47，1.00）。对于特定服务职业，风险估计接近于 1。所有非服务职业和工业类别的调整后比值比相似，服务职业工作是 PD 风险的唯一显着逆预测因子。 结论 未来的调查重点关注农业和服务职业类别中环境暴露中的生活方式因素是有必要的。是。 J.工业医学。 39:564-571, 2001。(C) 2001 Wiley-Liss, Inc.
Background The etiology of Parkinson's disease (PD) is considered to have a strong environmental component, but relatively few studies have investigated the potential association between occupation and the disease.Methods In a population-based case-control study we collected collected comprehensive occupational histories from all study participants, 144 case and 464 control subjects.Results Chi-square analysis revealed that working in an agricultural occupation increased estimated PD risk (OR = 1.74; 95% CI = 0.85, 3.60). In contrast, a history of ever working in a service occupation was negatively associated with PD risk (OR = 0.69; 95% CI = 0.47, 1.00). Risk estimates were close to one for specific service occupations. Adjusted odds ratios for all non-service occupational and industrial categories were similar, and working in a service occupation was the only significant inverse predictor of PD risk.Conclusions Future investigations focusing on lifestyle factors mid environmental exposures within the agricultural and service occupational categories are warranted. Am. J. Ind. Med. 39:564-571, 2001. (C) 2001 Wiley-Liss, Inc.