Activation of complement by Pityrosporum orbiculare.
Activation of complement by Pityrosporum orbiculare.
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轮状糠秕孢子菌激活补体。
DOI：
10.1111/1523-1747.ep12531644
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发表时间：
1983
影响因子：
6.5
通讯作者：
C. Collins
中科院分区：
文献类型：
--
作者：
P. Sohnle;C. Collins
评价了两种酵母样生物圆形糠秕孢子菌（变色念珠菌的假定病原体）和白色念珠菌激活人血清中补体的能力。通过以下方法测量补体激活：（a）在与生物体孵育后，使用人血清对兔红细胞溶解的抑制，和（B）通过酶联免疫吸附测定法定量酵母表面沉积的C3量。结果发现，两种微生物在正常血清或只有旁路途径完整的血清中激活补体的能力大致相同，即使C.白色念珠菌含有显著更大量的碳水化合物和能够与正常人血清中存在的抗体结合的抗原物质。由这两种微生物产生的皮肤病变中炎症的显著差异似乎与其补体激活能力无关，更可能是由于某些其他因素，如侵袭性或引起其他免疫反应的能力差异。
The ability to activate complement in human serum was evaluated for the two yeast-like organisms Pityrosporum orbiculare, the presumed etiologic agent of tinea versicolor, and Candida albicans. Complement activation was measured by: (a) using inhibition of rabbit red blood cell lysis by human serum after incubation with the organisms, and (b) quantitation of the amount of C3 deposited on the surface of the yeast by an enzyme-linked immunoabsorbent assay. It was found that both organisms had approximately equal ability to activate complement in normal serum or serum having only the alternative pathway intact, even though extracts of C. albicans contained significantly greater amounts of both carbohydrate and antigenic material capable of combining with the antibody present in normal human serum. The marked difference in inflammation in the cutaneous lesions produced by these two organisms does not appear to be related to their complement-activating ability and is more likely due to some other factor such as differences in invasiveness or in ability to elicit other immunologic reactions.