Antimicrobial strategies to reduce polymer biomaterial infections and their economic implications and considerations
Antimicrobial strategies to reduce polymer biomaterial infections and their economic implications and considerations
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DOI：
10.1016/j.ibiod.2018.10.005
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发表时间：
2019-01-01
影响因子：
4.8
通讯作者：
Whitehead, Kathryn A.
中科院分区：
文献类型：
--
作者：
Greenhalgh, Richard;Dempsey-Hibbert, Nina C.;Whitehead, Kathryn A.
医疗获得性感染（HAI）是一个世界性的问题，手术和植入聚合物医疗器械可能会加剧这一问题。使用包含抗菌策略的聚合物基医疗器械现在正成为一种越来越常规的尝试预防慢性感染和器械失效的方法。目前有广泛的潜在抗微生物剂被掺入到这样的聚合物中。然而，很难确定哪种抗菌剂提供最大的感染控制。用浸渍的聚合物材料替代现有方法的经济性进一步使问题复杂化。有人建议，应围绕医疗器械的植入开发整体系统方法，以最大限度地降低感染的潜在风险。然而，这些不同方法的使用仍在发展中。控制此类感染对个体患者的健康和医疗保健服务的经济影响非常重要。
Healthcare acquired infections (HAI's) are a worldwide problem that can be exacerbated by surgery and the implantation of polymeric medical devices. The use of polymer based medical devices which incorporate antimicrobial strategies are now becoming an increasingly routine way of trying to prevent the potential for reduce chronic infection and device failure. There are a wide range of potential antimicrobial agents currently being incorporated into such polymers. However, it is difficult to determine which antimicrobial agent provides the greatest infection control. The economics of replacing current methods with impregnated polymer materials further complicates matters. It has been suggested that the use of a holistic system wide approach should to be developed around the implantation of medical devices which minimises the potential risk of infection. However, the use of such different approaches is still being developed. The control of such infections is important for individual patient health and the economic implications for healthcare services.