Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys
Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys
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DOI：
10.1538/expanim.58.403
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发表时间：
2009-07-01
影响因子：
2.4
通讯作者：
Hisatsune, Tatsuhiro
中科院分区：
文献类型：
--
作者：
Aizawa, Ken;Ageyama, Naohide;Hisatsune, Tatsuhiro
新生神经元在海马体中不断产生，海马体可能参与包括学习和记忆在内的多种认知功能。然而，海马依赖的认知功能和成人神经发生水平都随着年龄的增长而逐渐减弱。很少有研究探索成人神经发生与认知功能之间的关系，特别是在灵长类动物中。在这项研究中，我们利用年轻和老年食蟹猴来评估学习表现和海马神经发生。老龄猴子的学习能力和成体神经发生明显减弱。有趣的是，学习表现和神经发生水平之间存在正相关。我们的研究结果表明，认知功能和成人神经发生在衰老过程中可能存在一些相互依赖的关系。
Newborn neurons are continuously produced in the hippocampus, which may be involved in several cognitive functions, including learning and memory, throughout life. However, both hippocampus-dependent cognitive functions and the level of adult neurogenesis are gradually attenuated as aging progresses. Few studies have explored the relationship between adult neurogenesis and cognitive functions, especially in primates. In this study, we evaluated learning performance and hippocampal neurogenesis utilizing young and aged cynomolgus monkeys. Significant attenuations in learning performance and adult neurogenesis were detected in aged monkeys. Interestingly, there was a positive correlation between learning performance and the level of neurogenesis. Our findings suggest that cognitive functions and adult neurogenesis may have some interdependent relationships during aging.