COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA
COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA
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DOI：
10.1038/352595a0
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发表时间：
1991-08-15
期刊：
影响因子：
64.8
通讯作者：
GREENWOOD, BM
中科院分区：
文献类型：
--
作者：
HILL, AVS;ALLSOPP, CEM;GREENWOOD, BM
一项关于西非儿童疟疾的大型病例对照研究表明，在西非常见但在其他种族群体中罕见的人类白细胞I类抗原（HLA-Bw 53）和HLA II类单倍型（DRB 1 *1302-DQB 1 *0501）与预防严重疟疾独立相关。在这一人群中，它们与镰状细胞血红蛋白变异体一样减少了发病率。这些数据支持的假设，主要组织相容性复合体基因的非凡的多态性主要是通过自然选择的传染性病原体。
A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.