Arsenic Species in Chicken Breast: Temporal Variations of Metabolites, Elimination Kinetics, and Residual Concentrations.
Arsenic Species in Chicken Breast: Temporal Variations of Metabolites, Elimination Kinetics, and Residual Concentrations.
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DOI：
10.1289/ehp.1510530
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发表时间：
2016-08
影响因子：
10.4
通讯作者：
Le XC
中科院分区：
文献类型：
--
作者：
Liu Q;Peng H;Lu X;Zuidhof MJ;Li XF;Le XC
在北美所有肉类中，鸡肉的人均消费量最高。用3-硝基-4-羟基苯胂酸（Roxarson，Rox）喂鸡的做法持续了60多年。然而，人们对鸡肉中残留的 Rox 和砷代谢物的去向知之甚少。我们的目的是确定鸡肉中 Rox 和代谢物的消除情况，并量化鸡肉中剩余的砷形态，为有意义的暴露评估提供必要的信息。我们对 1,600 只鸡进行了为期 35 天的饲养实验，其中一半是对照鸡，另一半在前 28 天饲喂添加 Rox 的饲料，然后在最后 7 天饲喂不含 Rox 的饲料。我们量化了 229 只鸡胸肉中各种砷的浓度。在饲喂 Rox 的鸡胸肉中检测到 Rox、砷甜菜碱、亚砷酸盐、一甲基胂酸、二甲基胂酸和一种新的砷代谢物。 Rox 喂养鸡中除砷甜菜碱外砷物质的浓度显着高于对照鸡。这些砷物质的消除半衰期为 0.4-1 天。 Rox饲喂结束后7天，Rox饲喂鸡中亚砷酸盐（3.1μg/kg）、Rox（0.4μg/kg）和新砷代谢物（0.8μg/kg）的浓度显着高于对照组。给鸡喂食 Rox 会增加胸肉中五种砷的浓度。虽然当停止喂养 Rox 时，大多数砷形态会迅速排出体外，但 Rox 喂养鸡体内残留的砷形态仍高于背景水平。刘强，彭华，陆X，Zuidhof MJ，李XF，乐XC。 2016.鸡胸肉中的砷形态：代谢物、消除动力学和残留浓度的时间变化。环境健康视角 124：1174–1181； http://dx.doi.org/10.1289/ehp.1510530
Chicken meat has the highest per capita consumption among all meat types in North America. The practice of feeding 3-nitro-4-hydroxyphenylarsonic acid (Roxarsone, Rox) to chickens lasted for more than 60 years. However, the fate of Rox and arsenic metabolites remaining in chicken are poorly understood. We aimed to determine the elimination of Rox and metabolites from chickens and quantify the remaining arsenic species in chicken meat, providing necessary information for meaningful exposure assessment. We have conducted a 35-day feeding experiment involving 1,600 chickens, of which half were control and the other half were fed a Rox-supplemented diet for the first 28 days and then a Rox-free diet for the final 7 days. We quantified the concentrations of individual arsenic species in the breast meat of 229 chickens. Rox, arsenobetaine, arsenite, monomethylarsonic acid, dimethylarsinic acid, and a new arsenic metabolite, were detected in breast meat from chickens fed Rox. The concentrations of arsenic species, except arsenobetaine, were significantly higher in the Rox-fed than in the control chickens. The half-lives of elimination of these arsenic species were 0.4–1 day. Seven days after termination of Rox feeding, the concentrations of arsenite (3.1 μg/kg), Rox (0.4 μg/kg), and a new arsenic metabolite (0.8 μg/kg) were significantly higher in the Rox-fed chickens than in the control. Feeding of Rox to chickens increased the concentrations of five arsenic species in breast meat. Although most arsenic species were excreted rapidly when the feeding of Rox stopped, arsenic species remaining in the Rox-fed chickens were higher than the background levels. Liu Q, Peng H, Lu X, Zuidhof MJ, Li XF, Le XC. 2016. Arsenic species in chicken breast: temporal variations of metabolites, elimination kinetics, and residual concentrations. Environ Health Perspect 124:1174–1181; http://dx.doi.org/10.1289/ehp.1510530