Nocturnal therapy with famotidine for 1 year is effective in preventing relapse of gastric ulcer
Nocturnal therapy with famotidine for 1 year is effective in preventing relapse of gastric ulcer
复制标题
法莫替丁夜间治疗1年可有效预防胃溃疡复发
DOI：
10.1111/j.1365-2036.1991.tb00017.x
复制
发表时间：
1991
影响因子：
7.6
通讯作者：
T. J. Cook
中科院分区：
文献类型：
--
作者：
R. Berlin;J. Root;T. J. Cook
采用多中心、双盲、随机、安慰剂对照试验，观察法莫替丁20 mg夜间给药对降低新近治愈的胃溃疡1年复发率的疗效。来自8个国家的20名研究人员随机对202名经内窥镜证实治愈的胃溃疡患者进行了研究。在6个月和12个月时重复进行内窥镜检查，或对与溃疡复发相容的症状进行重复内窥镜检查。对12个月累积寿命表复发的按方案分析显示，法莫替丁20 mg在减少胃溃疡复发方面优于安慰剂，分别为24%和50%(P<；0.01)。安慰剂和法莫替丁的耐受性都很好。由于夜间服用法莫替丁20毫克能有效防止胃溃疡在一年内复发，且耐受性良好，因此它为胃溃疡患者的长期治疗提供了一种治疗选择。
A multicentre, double‐blind, randomized, placebo‐controlled trial was undertaken to investigate the therapeutic efficacy of a nocturnal dose of famotidine 20 mg to reduce the 1 year relapse rate of recently healed gastric ulcers. Twenty investigators in eight countries randomized 202 patients with endoscopically confirmed healed gastric ulcers. Repeat endoscopies were performed at 6 and 12 months or for symptoms compatible with ulcer relapse. A per protocol analysis of cumulative life table relapse at 12 months showed that famotidine 20 mg was superior to placebo in reducing gastric ulcer relapse, 24 versus 50%, respectively (P < 0.01). Both placebo and famotidine were well tolerated. Since nocturnal dosing with famotidine 20 mg is effective in preventing gastric ulcer relapse over a 1‐year period and is well tolerated, it offers a therapeutic option for the long‐term treatment of patients with gastric ulcer.