Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
复制标题
DOI：
10.3389/fmicb.2013.00356
复制
发表时间：
2013
影响因子：
5.2
通讯作者：
Visick KL
中科院分区：
文献类型：
--
作者：
Norsworthy AN;Visick KL
细菌成功地定植于不同的生态位，因为它们可以感知各种环境信号并做出适当的反应。特别令人感兴趣的是细菌如何应对动物宿主成功感染过程中形成的多重复杂环境。研究细菌如何管理宿主多种环境的一种易于处理的模型系统是海洋细菌费氏弧菌与其鱿鱼宿主 Euprymna scolopes 之间的共生关系。 V. fischeri 会遇到许多不同的宿主环境，从最初与乌贼的接触到最终在一种称为光器官的特殊器官上定居。例如，在识别鱿鱼后，费氏弧菌在光器官外形成有效定殖所需的生物膜聚集体。然后细菌从生物膜中分散进入器官，在那里它们接触一氧化氮，一氧化氮是一种既可以充当信号又可以充当抗菌剂的分子。在成功管理这种潜在的敌对环境后，费氏弧菌细胞最终在光器官的深层隐窝中建立了自己的生态位，在那里细菌以信息素依赖的方式生物发光，这是 E. scolopes 利用这种表型来达到反捕食目的。 V. fischeri 管理这些环境以在 E. scolopes 定殖方面超越所有其他细菌物种的机制是一个重要且有趣的问题，它将为细菌如何成功地与宿主结合提供有价值的见解。本综述重点关注费氏弧菌建立这种精致的细菌-宿主相互作用的特定分子途径。
Bacteria successfully colonize distinct niches because they can sense and appropriately respond to a variety of environmental signals. Of particular interest is how a bacterium negotiates the multiple, complex environments posed during successful infection of an animal host. One tractable model system to study how a bacterium manages a host’s multiple environments is the symbiotic relationship between the marine bacterium, Vibrio fischeri, and its squid host, Euprymna scolopes. V. fischeri encounters many different host surroundings ranging from initial contact with the squid to ultimate colonization of a specialized organ known as the light organ. For example, upon recognition of the squid, V. fischeri forms a biofilm aggregate outside the light organ that is required for efficient colonization. The bacteria then disperse from this biofilm to enter the organ, where they are exposed to nitric oxide, a molecule that can act as both a signal and an antimicrobial. After successfully managing this potentially hostile environment, V. fischeri cells finally establish their niche in the deep crypts of the light organ where the bacteria bioluminesce in a pheromone-dependent fashion, a phenotype that E. scolopes utilizes for anti-predation purposes. The mechanism by which V. fischeri manages these environments to outcompete all other bacterial species for colonization of E. scolopes is an important and intriguing question that will permit valuable insights into how a bacterium successfully associates with a host. This review focuses on specific molecular pathways that allow V. fischeri to establish this exquisite bacteria–host interaction.
登录
查看更多内容
影响因子：
4.9
作者：
Bouchard, Josee Nina;Yamasaki, Hideo
通讯作者：
Yamasaki, Hideo
影响因子：
3.6
作者：
Carlson HK;Vance RE;Marletta MA
通讯作者：
Marletta MA
影响因子：
3.2
作者：
Georgellis, D;Lynch, AS;Lin, ECC
通讯作者：
Lin, ECC
影响因子：
4.4
作者：
Brennan, Caitlin A.;DeLoney-Marino, Cindy R.;Mandel, Mark J.
通讯作者：
Mandel, Mark J.
影响因子：
3.6
作者：
Bose, Jeffrey L.;Kim, Unmi;Stabb, Eric V.
通讯作者：
Stabb, Eric V.