Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults
Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults
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DOI：
10.1016/s0022-3999(03)00073-4
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发表时间：
2003-12-01
影响因子：
4.7
通讯作者：
Ring, C
中科院分区：
文献类型：
--
作者：
Burns, VE;Carroll, D;Ring, C
Objective: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. Methods: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. Results: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. Conclusion: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults. (C) 2003 Elsevier Inc. All rights reserved.
