DELAYED GASTRIC-EMPTYING INDUCED BY INHIBITORS OF NITRIC-OXIDE SYNTHASE IN RATS
DELAYED GASTRIC-EMPTYING INDUCED BY INHIBITORS OF NITRIC-OXIDE SYNTHASE IN RATS
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DOI：
10.1016/0014-2999(94)90236-4
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发表时间：
1994-04-21
影响因子：
5
通讯作者：
TACHE, Y
中科院分区：
文献类型：
--
作者：
PLOURDE, V;QUINTERO, E;TACHE, Y
研究了一氧化氮合酶抑制剂n- g -硝基- l -精氨酸甲酯对清醒大鼠非营养液胃排空的影响。n - g -单甲基- l-精氨酸（10 mg/kg灌胃）和n - g -硝基- l-精氨酸甲酯（3和10 mg/kg灌胃）对20 min胃排空率的抑制作用分别为34%、69%和84%，而n - g -硝基- l-精氨酸甲酯（0.3 mg/kg）和n - g -单甲基- l-精氨酸3 mg/kg灌胃无影响。l -精氨酸（300 mg/kg）可抑制n - g -硝基- l -精氨酸甲酯（3 mg/kg）的抑制作用，而d -精氨酸（300 mg/kg）则不能。n - g -硝基- l -精氨酸甲酯（0.3-10 mg/kg）可引起平均血压升高161+/-10 mm Hg，自发性高血压大鼠平均血压180+/-5 mm Hg时胃排空率为51.9+/-6.1%。这些数据表明，静脉注射一氧化氮合酶抑制剂，在抑制一氧化氮合酶的剂量下，通过与动脉血压变化无关的机制延迟胃排空。
The effect of the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester, on gastric emptying of a non-nutrient solution was investigated in conscious rats. N-G-Monomethyl-L-arginine (10 mg/kg i.v.) and N-G-nitro-L-arginine methyl ester (3 or 10 mg/kg i.v.) inhibited the 20-min rate of gastric emptying of liquids by 34%, 69% and 84% respectively, whereas the 0.3 mg/kg of N-G-nitro-L-arginine methyl ester or 3 mg/kg of N-G-monomethyl-L-arginine had no effect. The inhibitory effect of N-G-nitro-L-arginine methyl ester (3 mg/kg) was prevented by L-arginine (300 mg/kg i.v.), but not by D-arginine (300 mg/kg i.v.). N-G-Nitro-L-arginine methyl ester (0.3-10 mg/kg) induced a dose-related increase in mean blood pressure up to 161+/-10 mm Hg. Spontaneous hypertensive rats with a mean blood pressure of 180+/-5 mm Hg had a gastric emptying rate of 51.9+/-6.1%. These data indicate that NO synthase inhibitors given i.v. at doses that inhibit NO synthase, delay gastric emptying through mechanisms which are unrelated to changes in arterial blood pressure.