The immunologic and antioxidant effects of L-phenylalanine on the uterine implantation of mice embryos during early pregnancy
The immunologic and antioxidant effects of L-phenylalanine on the uterine implantation of mice embryos during early pregnancy
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L-苯丙氨酸对妊娠早期小鼠胚胎子宫着床的免疫和抗氧化作用
DOI：
10.14670/hh-29.1335
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发表时间：
2014-10-01
影响因子：
2
通讯作者：
Yang, Hongliang
中科院分区：
文献类型：
--
作者：
Dong, Yulan;Bai, Yongping;Yang, Hongliang
L-苯丙氨酸(L-Phe)是儿茶酚胺的人工合成前体。因为它不能被有机体合成，所以必须从环境中吸收。尽管L-苯丙氨酸被广泛使用，但L-苯丙氨酸是否对胚胎着床和发育有负面影响尚不清楚。本研究旨在探讨L-苯丙氨酸对妊娠小鼠胚胎着床发育及子宫免疫反应和抗氧化状态的影响。小鼠胚胎数减少57.6%，长径向胚胎体积减少2.8%(P>；0.05)和11.9%(P<0.05)。
L-phenylalanine (L-PHE) is a synthetic precursor of catecholamines. Because it cannot be synthesised by an organism, it must be absorbed from the environment. Despite the wide use of L-PHE, whether L-PHE has a negative impact on embryo implantation and development is poorly understood. This study attempted to determine the roles of L-PHE in embryo implantation and development and in the immune response and antioxidant status of the uterus in early pregnancy mice injected intraperitoneally with 320 mg/kg L-PHE. The embryo number of treated mice decreased by 57.6%, and the size of their embryos was reduced by 2.8% (P>0.05) along the long diameter and 11.9% (P