Bacterial Type IV secretion systems: versatile virulence machines.
Bacterial Type IV secretion systems: versatile virulence machines.
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DOI：
10.2217/fmb.11.150
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发表时间：
2012-02
影响因子：
3.1
通讯作者：
Graham JG
中科院分区：
文献类型：
--
作者：
Voth DE;Broederdorf LJ;Graham JG
许多细菌病原体利用多组分蛋白质复合物将大分子直接递送到其真核宿主细胞中以促进感染。一些革兰氏阴性病原体使用多功能IV型分泌系统（T4SS），其可以将DNA或蛋白质转运到宿主细胞中。T4SS代表了主要的细菌毒力决定因素，最近已成为旨在更好地了解和对抗传染病的密集研究工作的焦点。有趣的是，虽然两种主要类型的T4SS以类似的方式分泌蛋白质，但易位的“效应子”在不同生物体之间有很大差异。事实上，不同的效应库可能有助于生物体特异性宿主细胞相互作用和疾病结果。在这篇综述中，我们讨论了T4SS研究的现状，重点是人类细胞内的细菌病原体和用于操纵宿主细胞的各种易位效应子。
Many bacterial pathogens employ multicomponent protein complexes to deliver macromolecules directly into their eukaryotic host cell to promote infection. Some Gram-negative pathogens use a versatile type IV secretion system (T4SS) that can translocate DNA or proteins into host cells. T4SSs represent major bacterial virulence determinants and have recently been the focus of intense research efforts designed to better understand and combat infectious diseases. Interestingly, although the two major classes of T4SSs function in a similar manner to secrete proteins, the translocated “effectors” vary substantially from one organism to another. In fact, differing effector repertoires likely contribute to organism-specific host cell interactions and disease outcomes. In this review, we discuss the current state of T4SS research, with an emphasis on intracellular bacterial pathogens of humans and the diverse array of translocated effectors used to manipulate host cells.