Corneal nerve fibre damage precedes diabetic retinopathy in patients with Type2 diabetes mellitus
Corneal nerve fibre damage precedes diabetic retinopathy in patients with Type2 diabetes mellitus
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DOI：
10.1111/dme.12324
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发表时间：
2014-04-01
影响因子：
3.5
通讯作者：
Kerimoglu, H.
中科院分区：
文献类型：
--
作者：
Bitirgen, G.;Ozkagnici, A.;Kerimoglu, H.
AimsTo量化2型糖尿病患者角膜神经纤维和细胞的形态学改变与糖尿病视网膜病变严重程度的关系。方法对132例2型糖尿病患者和32例健康对照者的132只眼进行了活体角膜共聚焦显微镜检查。将糖尿病患者分为三组：无糖尿病视网膜病变患者、非增殖性糖尿病视网膜病变患者和增殖性糖尿病视网膜病变患者。前后基质角膜细胞，内皮细胞和基底上皮细胞密度和亚基底神经纤维structure.ResultsBasal上皮细胞，前基质角膜细胞和内皮细胞密度显着减少，观察只有在糖尿病视网膜病变患者。然而，神经纤维密度，神经分支密度和神经纤维长度减少，在没有糖尿病视网膜病变的患者，并逐步恶化，随着视网膜病变的严重程度增加。
AimsTo quantify the morphological alterations in corneal nerve fibres and cells in patients with Type2 diabetes mellitus in relation to the severity of diabetic retinopathy.MethodsOne hundred and thirty-two eyes of 132 patients with Type2 diabetes and 32 eyes of 32 healthy control subjects were evaluated with in vivo corneal confocal microscopy. Patients with diabetes were classified into three groups: patients without diabetic retinopathy, patients with non-proliferative diabetic retinopathy and patients with proliferative diabetic retinopathy. Anterior and posterior stromal keratocyte, endothelial cell and basal epithelial cell densities and sub-basal nerve fibre structure were evaluated.ResultsSignificant reductions in basal epithelial cell, anterior stromal keratocyte and endothelial cell densities were observed only in patients with diabetic retinopathy. However, nerve fibre density, nerve branch density and nerve fibre length were reduced in patients without diabetic retinopathy and worsened progressively with increasing severity of retinopathy.ConclusionsCorneal cell pathology occurs in patients with diabetic retinopathy, but corneal nerve fibre damage seems to precede the development of diabetic retinopathy.