Lack of association between genotype score and sprint/power performance in the Japanese population
Lack of association between genotype score and sprint/power performance in the Japanese population
复制标题
DOI：
10.1016/j.jsams.2016.06.005
复制
发表时间：
2017-01-01
影响因子：
4
通讯作者：
Fuku, Noriyuki
中科院分区：
文献类型：
--
作者：
Miyamoto-Mikami, Eri;Murakami, Haruka;Fuku, Noriyuki
目的：本研究的目的是检验基于先前发表的遗传多态性候选者的总基因型得分（TGS）与短跑/力量表现差异之间的关联。设计：病例对照关联研究。方法：我们分析了211名日本短跑/力量田径运动员的21个多态性，这些多态性以前与短跑/力量表现和相关表型相关（77个地区，72个国家和62个国际运动员）和649个日本对照使用TaqMan SNP基因分型测定。我们计算了21个多态性的TGS（理论上最佳多基因评分的最大值为100）。结果：所有组显示出相似的TGS（对照组：55.9 +/- 7.2，区域组：55.1 +/- 7.1，国家组：56.1 +/- 7.4，国际组：56.0 +/- 7.8，单向方差分析p=0.827）。21个多态性中有9个与以前的研究具有相同的效应方向（比值比>1.0），而12个具有相反的效应方向（比值比
Objectives: This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance.Design: Case-control association study.Methods: We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms.Results: All groups exhibited similar TGSs (control: 55.9 +/- 7.2, regional: 55.1 +/- 7.1, national: 56.1 +/- 7.4, and international: 56.0 +/- 7.8, p=0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio