Antidepressant drug interactions in the elderly - Understanding the P-450 system is half the battle in reducing risks
Antidepressant drug interactions in the elderly - Understanding the P-450 system is half the battle in reducing risks
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DOI：
10.3810/pgm.1999.11.780
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发表时间：
1999-11-01
影响因子：
4.2
通讯作者：
Cadieux, RJ
中科院分区：
文献类型：
--
作者：
Cadieux, RJ
年龄≥ 65岁的患者接受抗抑郁药治疗会增加药物不良事件的风险，因为年龄相关的生理变化、多药治疗和药物代谢的个体差异（由于遗传因素、并发疾病、饮食和消费习惯）。减少总药物负担、调整剂量水平和仔细选择适当的药物是避免药物不良相互作用的重要步骤。此外，应考虑各种抗抑郁药的记录和潜在药物相互作用，以及每类药物中的特定药物。在抗抑郁治疗的开始和维持过程中，每例老年患者都应单独治疗并仔细监测。
Antidepressant treatment in patients 65 years of age or older carries increased risks of adverse drug events because of age-related physiologic changes, polypharmacy, and individual variability in drug metabolism (due to genetic factors, concurrent disease, diet, and consumption habits). Reduction of total drug burden, adjustment of dose levels, and careful selection of an appropriate agent are important steps toward avoiding adverse drug interactions. In addition, the documented and potential drug interactions of the various classes of antidepressants, and specific agents within each class, should be considered. Each elderly patient should be treated individually and monitored carefully during the initiation and maintenance of antidepressant therapy.