CUTANEOUS REACTIONS TO RECOMBINANT CYTOKINE THERAPY
CUTANEOUS REACTIONS TO RECOMBINANT CYTOKINE THERAPY
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DOI：
10.1016/0190-9622(95)91382-3
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发表时间：
1995-09-01
影响因子：
13.8
通讯作者：
GASPARI, AA
中科院分区：
文献类型：
--
作者：
ASNIS, LA;GASPARI, AA
细胞因子对几种基本的稳态机制至关重要，例如发热、急性期反应、伤口愈合、造血、炎症、细胞和体液免疫应答以及肿瘤消退。由于重组DNA技术的进步，重组细胞因子可用作治疗剂。它们已被用于转移性癌症和免疫缺陷，作为自然发生的或药物诱导的贫血或白细胞减少症的治疗，并且它们也已被应用于一些皮肤疾病。细胞因子治疗可导致毒性反应，影响许多器官系统，特别是皮肤。这些反应常见且多样，范围从轻微注射部位反应、瘙痒和潮红到危及生命的自身免疫性疾病、重度红皮病或大疱性皮肤反应。本文综述了目前临床使用或正在研究的主要细胞因子，并介绍了这些药物的皮肤并发症。
Cytokines are critical to several fundamental homeostatic mechanisms such as fever, acute phase reactions, wound healing, hematopoiesis, inflammation, cellular and humoral immune responses, and tumor regression. As a result of advances in recombinant DNA technology, recombinant cytokines are available as therapeutic agents. They have been used for metastatic cancers and immunodeficiencies, as a therapy for naturally occurring or drug-induced anemias or leukopenias, and they have also been applied to some cutaneous disorders. Cytokine therapy can result in toxic reactions that affect many organ systems, especially the skin. These reactions are common and diverse, ranging from minor injection site reactions, pruritus, and flushing to life-threatening autoimmune disorders, severe erythroderma, or bullous skin reactions. This review focuses on the major cytokines that are in current clinical use or under investigation and describes the cutaneous complications of these agents.