GONADECTOMY AND SENSITIVITY TO ELECTRIC-SHOCK IN RAT
GONADECTOMY AND SENSITIVITY TO ELECTRIC-SHOCK IN RAT
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DOI：
10.1016/0031-9384(77)90149-4
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发表时间：
1977-01-01
影响因子：
2.9
通讯作者：
FESSLER, RG
中科院分区：
文献类型：
--
作者：
BEATTY, WW;FESSLER, RG
采用改良的退缩跳跃技术评估了性腺切除术和激素替代对电击性典型反应的影响。卵巢切除术增加了体重，但对休克敏感性的任何测量都没有影响。在任何年龄段的男性性腺切除术导致体重增加减少，但在男性的性腺切除术对休克阈值的影响随手术年龄而变化：新生儿性腺切除术增加了对休克的敏感性，反映在所有措施的阈值较低;成年性腺切除术并没有可靠地影响任何休克阈值和阉割在7周龄降低只有退缩和洗牌阈值，而不影响跳跃阈值。睾丸酮注射可提高性腺切除术降低的休克阈值，这种作用在睾丸去势组中最为明显。新生儿性腺切除术是否消除了睾丸激素对疼痛敏感性的组织影响值得怀疑。此外，性腺切除术后体重和休克反应性的变化可以相对独立的方式发生。
The effects of gonadectomy and hormone replacement on sex-typical responses to electric shock were assessed using a modification of the flinch-jump technique. Ovariectomy increased body weight but had no effect on any measure of sensitivity to shock. Gonadectomy in males at any age resulted in reduced weight gain but the effect of gonadectomy on shock thresholds in males varied with the age of operation: neonatal gonadectomy increased sensitivity to shock as reflected in lower thresholds on all measures; adult gonadectomy did not reliably affect any shock threshold and castration at 7 wk of age lowered only flinch and shuffle thresholds without affecting jump thresholds. Testosterone injections elevated shock thresholds depressed by gonadectomy and this effect was most evident in the neonatally castrated group. It is doubtful that neonatal gonadectomy removes an organizational influence of testicular hormones on pain sensitivity. Moreover, changes in body weight and reactivity to shock following gonadectomy can occur in a relatively independent fashion.