Nonimmunological production of leukotrienes induced by platelet-activating factor.

Nonimmunological production of leukotrienes induced by platelet-activating factor.
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血小板激活因子诱导的白三烯的非免疫产生。

DOI:
10.1126/science.7123233
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发表时间:
1982
期刊:
影响因子:
56.9
通讯作者:
R. Murphy
R. Murphy
中科院分区:
综合性期刊1区
文献类型:
--
作者:
N. Voelkel;S. Worthen;J. Reeves;P. Henson;R. Murphy

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血小板活化因子引起快速肺血管收缩和水肿,在离体肺灌注无白蛋白盐溶液缺乏形成的血液元素。这些影响可能部分是由于白三烯D4和C4的作用,这是由血小板活化因子刺激后的肺流出物中的生物测定和高压液相色谱法确定的。这些发现有助于阐明血小板活化因子在过敏反应和可能在其他形式的肺损伤中的一些有害作用。
Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.
DOI: 10.1016/0003-2697(81)90162-7
发表时间: 1981
影响因子: 2.9
作者:
Mathews,WR;Rokach,J;Murphy,RC
通讯作者: Murphy,RC
1-O-十六烷基/十八烷基-2-乙酰基-sn-甘油基-3-磷酸胆碱(血小板激活因子)激活兔血小板磷脂酶和血栓素合成。
DOI: 10.1016/0005-2760(81)90208-3
发表时间: 1981
期刊: Biochimica et biophysica acta
影响因子: --
作者:
Shaw,JO;Klusick,SJ;Hanahan,DJ
通讯作者: Hanahan,DJ