Neural tube defects: prevention by vitamin supplements.
Neural tube defects: prevention by vitamin supplements.
复制标题
神经管缺陷：通过补充维生素来预防。
DOI：
10.1542/peds.69.4.498
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发表时间：
1982
期刊：
影响因子：
8
通讯作者：
R. Smithells
中科院分区：
文献类型：
--
作者：
R. Smithells
神经管缺陷（NTD）一直是流行病学研究的对象比任何其他类型的出生缺陷。这部分是因为它们在出生时（近年来，在出生前）就已经被识别出来，部分是因为它们的后果通常是灾难性的：它们会导致死亡或致残。
Neural tube defects (NTD) have been the object of more intense epidemiologic study than any other kind of birth defect. This is in part because of their ready recognition at birth (and, in recent years, before birth) and in part because their consequences are usually catastrophic: they kill or they cripple.
Regarding their cause, no single genetic or environmental agent has been identified (or is likely to be) and a multifactorial basis is assumed. If failure of neural tube closure results from the additive effects of several adverse factors, removal or correction of any one might shift the developmental balance across the threshold from NTD to normality.