The role of leucine in the regulation of protein metabolism
The role of leucine in the regulation of protein metabolism
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DOI：
10.1093/jn/135.6.1553s
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发表时间：
2005-06-01
影响因子：
4.2
通讯作者：
Garlick, PJ
中科院分区：
文献类型：
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作者：
Garlick, PJ
体内和体外研究均表明，非常高剂量的亮氨酸可以刺激肌肉蛋白质合成，这种作用在体内通过响应亮氨酸剂量而分泌的胰岛素而增强。高亮氨酸还可以抑制骨骼肌和肝脏中的蛋白质降解。相反，在正常生理水平下，通过输注增加亮氨酸浓度通过增强其对胰岛素的敏感性来刺激肌肉蛋白质合成。它的结论是，亮氨酸在体内的作用是提供一个信号，氨基酸是可用的，这与胰岛素的能量可用性的信号相结合，刺激肌肉蛋白质的合成。
Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response to the leucine dose. High leucine can also inhibit protein degradation in skeletal muscle, as well as in liver. In contrast, at normal physiological levels, increasing leucine concentration by infusion stimulates muscle protein synthesis by enhancing its sensitivity to insulin. It is concluded that the role of leucine in vivo is to provide a signal that amino acids are available, which in combination with the signal of energy availability from insulin, stimulates muscle protein synthesis.