Carotenoids and cardiovascular disease
Carotenoids and cardiovascular disease
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DOI：
10.1007/s11883-009-0065-z
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发表时间：
2009-11-01
影响因子：
5.8
通讯作者：
Riccioni, Graziano
中科院分区：
文献类型：
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作者：
Riccioni, Graziano
类胡萝卜素是一类主要存在于植物中的天然脂溶性色素。由于它们的化学结构和与生物膜的相互作用，它们具有潜在的抗氧化生物学特性。饮食中最丰富的类胡萝卜素是β-胡萝卜素、番茄红素、叶黄素、β-隐黄质、玉米黄质和虾青素。许多流行病学研究都支持这一假设，即抗氧化剂可以作为一种廉价的预防手段，并可能治疗心血管疾病，即使干预性试验的结果是混合的，一些积极的发现，许多无效的发现，并在某些高危人群中的伤害的一些建议。最近对精心挑选的人群（如处于高水平氧化应激下的人群）进行的较小规模的干预性研究取得了很大的积极成果。这表明我们需要更多的假设驱动和严格的临床试验设计。本文综述了近年来关于类胡萝卜素，特别是番茄红素和虾青素在心血管疾病治疗中的应用研究。
Carotenoids are a class of natural fat-soluble pigments found principally in plants. They have potential antioxidant biological properties due to their chemical structure and interaction with biological membranes. The most abundant carotenoids in the diet are beta-carotene, lycopene, lutein, beta-cryptoxanthin, zeaxanthin, and astaxanthin. Numerous epidemiologic studies have supported the hypothesis that antioxidants could be used as an inexpensive means of prevention, and possibly treatment, of cardiovascular diseases, even though findings from interventional trials have been mixed, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations. Recent smaller interventional studies with carefully chosen populations, such as those under high levels of oxidative stress, have yielded largely positive results. This suggests that we need more hypothesisdriven and rigorous clinical trial designs. The aim of this review is to examine the published studies about the use of carotenoids, especially lycopene and astaxanthin, in the treatment of cardiovascular diseases.