Congruence of imaging estimators and mechanical measurements of viscoelastic properties of soft tissues
Congruence of imaging estimators and mechanical measurements of viscoelastic properties of soft tissues
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DOI：
10.1016/j.ultrasmedbio.2007.04.012
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Parker, Kevin J.
中科院分区：
文献类型：
--
作者：
Zhang, Man;Castaneda, Benjamin;Parker, Kevin J.
软组织的生物力学特性在广泛的医学应用中具有重要意义，例如手术模拟和通过弹性成像方式规划和检测病变。目前，文献中的数据有限且相互矛盾。此外，为了评估活体组织的生物力学特性，必须开发和验证可靠的基于成像的估计器。出于这些原因，我们开发并比较了两种独立的定量方法-爬行波估计器(CRE)和机械测量(MM)用于软组织表征。CRE方法成像横波干涉图样，由此可以确定横波速度，从而可以得到杨氏模数。MM方法提供了软组织的复数杨氏模数，从中可以提取弹性和粘性行为。本文系统地比较了这两种技术对明胶模型、小牛肝、热处理小牛肝和人前列腺的测量。观察到肝脏和前列腺组织的杨氏模数随频率的增加而略有增加。两种方法的实验结果高度一致，表明CRE和MM方法可以可靠地用于研究其他软组织的粘弹性性质，而且CRE具有几乎实时和原位操作的优点。(电子邮件：parker@seas.rochester.edu)(C)2007年世界医学和生物学超声联合会。
Biomechanical properties of soft tissues are important for a wide range of medical applications, such as surgical simulation and planning and detection of lesions by elasticity imaging modalities. Currently, the data in the literature is limited and conflicting. Furthermore, to assess the biomechanical properties of living tissue in vivo, reliable imaging-based estimators must be developed and verified. For these reasons, we developed and compared two independent quantitative methods - crawling wave estimator (CRE) and mechanical measurement (MM) for soft tissue characterization. The CRE method images shear wave interference patterns from which the shear wave velocity can be determined and hence the Young's modulus can be obtained. The MM method provides the complex Young's modulus of the soft tissue from which both elastic and viscous behavior can be extracted. This article presents the systematic comparison between these two techniques on the measurement of gelatin phantom, veal liver, thermal-treated veal liver and human prostate. It was observed that the Young's moduli of liver and prostate tissues slightly increase with frequency. The experimental results of the two methods are highly congruent, suggesting CRE and MM methods can be reliably used to investigate viscoelastic properties of other soft tissues, with CRE having the advantages of operating in nearly real time and in situ. (E-mail: parker@seas.rochester.edu) (C) 2007 World Federation for Ultrasound in Medicine & Biology.