MicroRNA regulation of neural plasticity and memory
MicroRNA regulation of neural plasticity and memory
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DOI：
10.1016/j.nlm.2011.04.004
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发表时间：
2011-07-01
影响因子：
2.7
通讯作者：
Mattick, John S.
中科院分区：
文献类型：
--
作者：
Bredy, Timothy W.;Lin, Quan;Mattick, John S.
microRNAs（miRNAs）是一类内源性小分子非编码RNA，通过与靶mRNA的3 '端非翻译区互补结合而介导转录后基因沉默。这些小RNA在树突中的瞬时和局部表达，它们以活性依赖性方式响应的能力，以及观察到单个miRNA可以同时调节许多基因，使得脑特异性miRNA成为微调与神经可塑性和记忆形成相关的基因表达的理想候选者。在这里，我们提供了一个概述，目前的文献，支持的建议，非编码RNA介导的基因功能的调节代表了一个重要的，但未得到充分重视，层的表观遗传控制，有助于学习和记忆在成人大脑。(c)2011 Elsevier Inc. All rights reserved.
MicroRNAs (miRNAs) are a class of endogenous, small non-coding RNAs that mediate post-transcriptional gene silencing by complementary binding to the 3'untranslated region of target mRNAs. The transient and localized expression of these small RNAs in dendrites, their capacity to respond in an activity-dependent manner, and the observation that a single miRNA can simultaneously regulate many genes, make brain-specific miRNAs ideal candidates for the fine-tuning of gene expression associated with neural plasticity and memory formation. Here we provide an overview of the current literature, which supports the proposal that non-coding RNA-mediated regulation of gene function represents an important, yet underappreciated, layer of epigenetic control that contributes to learning and memory in the adult brain. (c) 2011 Elsevier Inc. All rights reserved.