The promising antitumour drug disulfiram inhibits viability and induces apoptosis in cardiomyocytes
The promising antitumour drug disulfiram inhibits viability and induces apoptosis in cardiomyocytes
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有前途的抗肿瘤药物双硫仑抑制心肌细胞的活力并诱导细胞凋亡
DOI：
10.1016/j.biopha.2018.09.123
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发表时间：
2018
影响因子：
7.5
通讯作者：
Li Xinming
中科院分区：
文献类型：
--
作者：
Li Yanfei;Shen Junwei;Fang Ming;Huang Xiaoliu;Yan Hongwei;Jin Yueling;Li Jue;Li Xinming
双硫仑(DSF)广泛用于酒精滥用的治疗，是一种很有前途的抗肿瘤药物，可以抑制肿瘤细胞的活力，逆转肿瘤的耐药性，并诱导细胞凋亡。然而，其对心肌细胞的潜在副作用仍不清楚。本研究表明，DSF不仅能抑制心肌细胞的活性和活性，而且能促进细胞的凋亡。此外，我们还发现心肌细胞比癌细胞对DSF更敏感。此外，在DSF处理的心肌细胞中，STAT3的表达显著下调，STAT3是心肌细胞活性的关键调节因子。最后，我们还通过实验比较表明，聚乙二醇是一种有希望的溶剂，可以减少DSF的不良反应，从而扩大其潜在的临床应用范围。
Disulfiram (DSF), widely used for treating alcohol abuse, is a promising antitumour drug that inhibits tumour cell viability, reverses cancer drug resistance and induces apoptosis. However, its potential side effects on cardiomyocytes remain unknown. This study demonstrated that DSF can not only inhibit cardiomyocyte viability and activity but also promote cell apoptosis. Furthermore, we revealed that cardiomyocytes were more sensitive to DSF than cancer cells. Moreover, the expression of STAT3, a key regulator of cardiomyocyte viability, was significantly down-regulated in cardiomyocytes treated with DSF. Finally, we also used experimental comparisons to indicate that PEG is a promising solvent for decreasing the adverse side effects of DSF, thereby expanding its potential range of clinical applications.